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首页> 外文期刊>Research Opinions in Animal & Veterinary Sciences >Evaluation of effectiveness of pest des petits ruminants vaccine in Northern Tanzania
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Evaluation of effectiveness of pest des petits ruminants vaccine in Northern Tanzania

机译：坦桑尼亚北部小反刍动物有害生物疫苗的有效性评估

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After the incursion of Peste des Petits ruminants (PPR) in Tanzania in 2008, Ministry of Livestock and Fisheries Development (MLDF) in collaboration with development partners started to control the disease by vaccination of sheep and goats through the Vaccination for Control of Neglected Animal Diseases in Africa (VACNADA) project. Vaccination was carried out in Northern and Lake Zones, where Tanzania borders Kenya, the known entry point for the disease in East Africa. A cross sectional epidemiological study was carried out in the Tarime district to evaluate the effectiveness of PPR control by vaccination implemented in Tanzania. A total of 360 serum samples, 180 pre-vaccination and 180 post-vaccination of sheep and goats were randomly retrieved from lake zone. Retrieved serum samples were serologically analyzed using a monoclonal antibody-based competitive enzyme-linked immunosorbent assay (c-ELISA) to assess the seroprevalence of PPR before and after vaccination. There was a statistically significant difference in seroconversion between pre- and post-vaccination samples. The pre-vaccination and post-vaccination seroprevalence of PPR in sheep and goats from nine representative villages were found to be 3.3% and 71.3% respectively (P<0.0001). Mean change in seroconversion rates across villages was found to be 67.8% (range 45 to 80%). Significantly higher acquisition of antibodies following vaccination suggests positive response that could be protective for sheep and goats against PPR. Efforts should be made to upscale vaccination coverage as well as carrying out further studies to evaluate the role of PPR vaccination in protection against this disease in small ruminants.
机译：在2008年坦桑尼亚的小反刍兽疫（PPR）入侵之后，畜牧和渔业发展部（MLDF）与发展伙伴合作，开始通过控制被忽视的动物疾病的疫苗接种来对绵羊和山羊进行疫苗接种来控制这种疾病非洲（VACNADA）项目。疫苗接种是在北部和湖泊地区进行的，坦桑尼亚与肯尼亚接壤，肯尼亚是东非已知的该病入口点。在Tar​​ime地区进行了横断面流行病学研究，以评估坦桑尼亚实施的疫苗接种控制PPR的有效性。从湖区随机抽取了总共360份血清样品，180份疫苗接种前和180份疫苗接种后的绵羊和山羊。使用基于单克隆抗体的竞争性酶联免疫吸附试验（c-ELISA）对提取的血清样品进行血清学分析，以评估疫苗接种前后PPR的血清阳性率。接种前后的血清转化率在统计学上有显着差异。发现来自9个代表性村庄的绵羊和山羊的PPR疫苗接种前和疫苗接种后血清阳性率分别为3.3％和71.3％（P <0.0001）。各个村庄的血清转化率平均变化为67.8％（范围从45％到80％）。接种疫苗后抗体的获得率显着提高，表明阳性反应可能对绵羊和山羊具有预防PPR的作用。应该努力扩大疫苗接种的覆盖面，并进行进一步的研究以评估PPR疫苗在小反刍动物中预防这种疾病的作用。

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