...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Revista Brasileira de Anestesiologia >Midazolam por via oral como medica??o pré-anestésica em crian?as e adolescentes com paralisia cerebral: estudo comparativo das varia??es do índice bispectral
【24h】

Midazolam por via oral como medica??o pré-anestésica em crian?as e adolescentes com paralisia cerebral: estudo comparativo das varia??es do índice bispectral

机译：口服咪达唑仑作为小儿脑瘫儿童和青少年的麻醉前用药：双光谱指数变化的比较研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND AND OBJECTIVES: Midazolam is a benzodiazepine with hypnotic action widely used as pre-anesthetic medication in pediatric anesthesia. Children with cerebral palsy (CP) also benefit from the use of midazolam, but its effects on this group of patients, who present several particularities, including changes at the site of action of midazolam, are still unknown. The objective of this study was to evaluate the effects of midazolam, when used as pre-anesthetic medication, on the bispectral index (EEG-BIS) of patients with cerebral palsy. METHODS: Two groups of patients were evaluated: one group with the diagnosis of CP and the other without central and peripheral nervous system disorders. The EEG-BIS was recorded in the room, the day before the surgery, and at the day of the surgery, 40 minutes after the administration of 0.6 mg.kg-1 of oral midazolam. Patients with a history of paradoxal reaction to midazolam as well as patients in the control group who were using other medications were excluded. RESULTS: Seventy-seven patients of both genders, 4 to 18 years old, participated in this study. Differences in EEG-BIS between both groups were not detected. After the use of midazolam EEG-BIS decreased in both groups with a statistically significant difference in each group. Statistically significant intergroup differences were not observed. CONCLUSIONS: Midazolam, used as pre-anesthetic medication, at a dose of 0.6 mg.kg-1, reduced basal EEG-BIS without characterizing hypnosis and without statistically significant differences between the study groups.
机译：背景与目的：咪达唑仑是一种具有催眠作用的苯二氮卓类药物，广泛用作儿科麻醉中的麻醉前药物。脑性瘫痪（CP）患儿也可从使用咪达唑仑中获益，但其对这组患者的影响尚不明确，这些患者表现出几种特殊性，包括咪达唑仑作用部位的变化。这项研究的目的是评估咪达唑仑在用作麻醉剂之前对脑瘫患者的双谱指数（EEG-BIS）的影响。方法：对两组患者进行了评估：一组诊断为CP，另一组没有中枢和​​周围神经系统疾病。在手术前一天以及在手术当天，口服0.6 mg.kg-1的咪达唑仑后，在房间记录EEG-BIS。对咪达唑仑有悖论反应史的患者以及对照组中使用其他药物的患者均被排除在外。结果：4至18岁的77名男女患者参加了这项研究。未检测到两组之间的EEG-BIS有差异。咪达唑仑使用后，两组脑电图-BIS均下降，各组差异均有统计学意义。没有观察到统计学上显着的组间差异。结论：咪达唑仑以0.6 mg.kg-1的剂量用作麻醉前药物，可降低基础脑电图BIS，而无催眠作用，且研究组之间无统计学差异。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号