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首页> 外文期刊>Revista Brasileira de Anestesiologia >Níveis de seda??o determinados pela clonidina e midazolam na medica??o pré-anestésica: avalia??o clínica e eletroencefalográfica bispectral
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Níveis de seda??o determinados pela clonidina e midazolam na medica??o pré-anestésica: avalia??o clínica e eletroencefalográfica bispectral

机译：麻醉前药物中可乐定和咪达唑仑测定的蚕丝水平：临床和双谱脑电图评估

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BACKGROUND AND OBJECTIVES: This study aimed at evaluating clonidine - an a2-agonist - and midazolam - a benzodiazepine - sedative effects in preanesthetic medication by clinical and electroencephalographic analysis. METHODS: After institutional approval and their informed written consent, participated in this study 45 patients aged 18 to 65 years, physical status ASA I, who were randomly distributed in placebo (P), clonidine (C) or midazolam (M) groups. Patients were premedicated with oral placebo, 150 μg clonidine or 15 mg midazolam 60 minutes before anesthetic induction (n = 15 per group). Monitoring consisted of electrocardiogram (DII), non-invasive blood pressure, heart rate, oxygen saturation, respiratory rate, axillary and operating room temperature and bispectral electroencephalography to determine bispectral index (BIS). These attributes and sedation scale (1-anxious, 2-calm, 3-sleepy, 4-sleeping with reflex, 5-sleeping without reflex) were obtained at 0 (M0), 15 (M15), 30 (M30), 40 (M40), 50 (M50) and 60 (M60) minutes after medication. RESULTS: There were no significant differences in respiratory, hemodynamic and temperature parameters. There has been a significant difference among groups in sedation scale (M60: M=C>P) and BIS (M50 and M60: M=C>P). CONCLUSIONS: In our conditions, clonidine and midazolam have determined similar sedation levels in patients ASA I when evaluated by sedation scale and BIS. No hemodynamic and respiratory changes were observed with both drugs.
机译：背景与目的：本研究旨在通过临床和脑电图分析来评估可乐定（一种α2-激动剂）和咪达唑仑（一种苯二氮卓类药物）在麻醉前药物中的镇静作用。方法：经机构批准并获得知情书面同意后，本研究参加了45位18至65岁，身体状况为ASA I的患者，这些患者被随机分为安慰剂（P），可乐定（C）或咪达唑仑（M）组。麻醉诱导前60分钟，患者接受口服安慰剂，150μg可乐定或15 mg咪达唑仑的药物治疗（每组n = 15）。监测包括心电图（DII），无创血压，心率，血氧饱和度，呼吸频率，腋窝和手术室温度以及双谱脑电图，以确定双谱指数（BIS）。在0（M0），15（M15），30（M30），40（0时）获得这些属性和镇静等级（1焦虑，2平静，3困，反射的4睡眠，5反射无反射的5睡眠）。服药后50分钟（M50）和60（M60）分钟。结果：呼吸，血液动力学和温度参数无明显差异。镇静等级（M60：M = C> P）和BIS（M50和M60：M = C> P）在各组之间存在显着差异。结论：在我们的情况下，可乐定和咪达唑仑在通过镇静量表和BIS进行评估时，已确定ASA I患者的镇静水平相似。两种药物均未观察到血液动力学和呼吸变化。

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