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首页> 外文期刊>Radiation oncology >Expression of the senescence marker p16INK4a in skin biopsies of acute lymphoblastic leukemia survivors: a pilot study
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Expression of the senescence marker p16INK4a in skin biopsies of acute lymphoblastic leukemia survivors: a pilot study

机译：急性淋巴细胞白血病幸存者皮肤活检中衰老标记p16 INK4a 的表达

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Background Most childhood cancer survivors will develop ionizing radiation treatment-related health conditions that, in many instances, resemble age-associated pathologies. Treatment-induced premature senescence could be an underlying mechanism. Findings Here we wanted to know whether the expression of p16INK4a, a senescence/aging biomarker, is increased in skin biopsies of acute lymphoblastic leukemia survivors (ALL), previously exposed to chemotherapy and radiation therapy. Several years post-treatments, we found p16INK4a mRNA levels are 5.8 times higher in scalp skin biopsies (targeted by cranial irradiation therapy) compared to buttocks skin biopsies (n?=?10, p?=?0.01). Conclusions These results demonstrate for the first time that premature senescence is induced in pediatric cancer survivors and that p16INK4a expression could be used as a potential biomarker in this population.
机译：背景大多数儿童癌症幸存者将发展与电离辐射治疗有关的健康状况，在许多情况下，这些疾病类似于与年龄相关的病理。治疗诱导的过早衰老可能是潜在的机制。研究结果在这里我们想知道p16INK4a（一种衰老/衰老生物标志物）的表达在急性淋巴细胞白血病幸存者（ALL）的皮肤活检中是否增加了，该活检曾接受过化学疗法和放射疗法。治疗后数年，我们发现头皮皮肤活检（通过颅骨放射疗法靶向）中的p16INK4a mRNA水平比臀部皮肤活检（n≥10，p≥0.01）高5.8倍。结论这些结果首次证明，小儿癌症幸存者可诱发早衰，并且p16INK4a表达可作为该人群的潜在生物标志物。

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