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A comparative study on the volume and localization of the internal gross target volume defined using the seroma and surgical clips based on 4DCT scan for external-beam partial breast irradiation after breast conserving surgery

机译:保乳手术后使用基于4DCT扫描的血清和手术夹确定的内部总目标体积和局部总目标体积的比较研究

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Background To explore the volume and localization of the internal gross target volume defined using the seroma and/or surgical clips based on the four-dimensional computed tomography (4DCT) during free-breathing. Methods Fifteen breast cancer patients after breast-conserving surgery (BCS) were recruited for EB-PBI. On the ten sets CT images, the gross target volume formed by the clips, the seroma, both the clips and seroma delineated by one radiation oncologist and defined as GTVc, GTVs and GTVc?+?s, respectively. The ten GTVc, GTVs and GTVc?+?s on the ten sets CT images produced the IGTVc, IGTVs, IGTVc?+?s, respectively. The IGTV volume and the distance between the center of IGTVc, IGTVs, IGTVc?+?s were all recorded. Conformity index (CI), degree of inclusion (DI) were calculated for IGTV/IGTV, respectively. Results The volume of IGTVc?+?s were significantly larger than the IGTVc and IGTVs (p?
机译:背景技术探讨在自由呼吸过程中使用基于血清和/或手术夹的三维计算机断层扫描(4DCT)定义的内部总目标体积的大小和位置。方法选择15例保乳术后乳腺癌患者进行EB-PBI检查。在十组CT图像上,由夹子,血清肿,夹子和血清肿形成的总目标体积由一位放射肿瘤学家描绘,分别定义为GTVc,GTV和GTVc ++ s。十组CT图像上的十个GTVc,GTV和GTVc ++分别产生了IGTVc,IGTV,IGTVc ++ s。记录IGTV的体积和IGTVc,IGTV,IGTVc ++ s的中心之间的距离。分别计算了IGTV / IGTV的合格指数(CI)和包含度(DI)。结果IGTVc ++ s的体积明显大于IGTVc和IGTV(p <0.05)。 IGTVc与IGTVc?+?s的DI之间存在显着差异,IGTV与IGTVc?+?s的DI之间存在显着差异。 IGTV / IGTV的配置项之间存在显着差异。 IGTV / IGTV的DI和CI与它们的质心距离呈负相关(r <0,p <0.05)。结论根据手术夹和血清肿所画的IGTV之间存在体积差异和空间失配。定义为血清和手术夹的IGTV提供了“真正的”移动GTV的最佳整体表示。

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