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首页> 外文期刊>Radiation oncology >Pretreatment carcinoembryonic antigen level is a risk factor for para-aortic lymph node recurrence in addition to squamous cell carcinoma antigen following definitive concurrent chemoradiotherapy for squamous cell carcinoma of the uterine cervix
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Pretreatment carcinoembryonic antigen level is a risk factor for para-aortic lymph node recurrence in addition to squamous cell carcinoma antigen following definitive concurrent chemoradiotherapy for squamous cell carcinoma of the uterine cervix

机译：宫颈鳞状上皮癌同时行放化疗后，除鳞状上皮癌抗原外，预处理前癌胚抗原水平是主动脉旁淋巴结复发的危险因素。

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Background To identify pretreatment carcinoembryonic antigen (CEA) levels as a risk factor for para-aortic lymph node (PALN) recurrence following concurrent chemoradiotherapy (CCRT) for cervical cancer. Methods From March 1995 to January 2008, 188 patients with squamous cell carcinoma (SCC) of the uterine cervix were analyzed retrospectively. No patient received PALN irradiation as the initial treatment. CEA and squamous cell carcinoma antigen (SCC-Ag) were measured before and after radiotherapy. PALN recurrence was detected by computer tomography (CT) scans. We analyzed the actuarial rates of PALN recurrence by using Kaplan-Meier curves. Multivariate analyses were carried out with Cox regression models. We stratified the risk groups based on the hazard ratios (HR). Results Both pretreatment CEA levels ≥ 10 ng/mL and SCC-Ag levels p p p Conclusions Pretreatment CEA ≥ 10 ng/mL is an additional risk factor of PALN relapse following definitive CCRT for SCC of the uterine cervix in patients with pretreatment SCC-Ag levels
机译：背景技术要确定宫颈癌的同期放化疗后，癌前胚胎抗原（CEA）水平是主动脉旁淋巴结（PALN）复发的危险因素。方法回顾性分析1995年3月至2008年1月收治的188例宫颈鳞癌患者的临床资料。没有患者接受PALN辐射作为初始治疗。放疗前后测量CEA和鳞状细胞癌抗原（SCC-Ag）。通过计算机断层扫描（CT）扫描检测到PALN复发。我们使用Kaplan-Meier曲线分析了PALN复发的精算率。用Cox回归模型进行多变量分析。我们根据危险比（HR）对风险类别进行了分层。结果术前CEA≥10 ng / mL和SCC-Ag水平p p p p结论结论术前CEA≥10 ng / mL是CCRT明确的SCC-Ag水平患者子宫颈SCC后PALN复发的另一危险因素

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