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Adenovirus pneumonia treated with Cidofovir in an immunocompetent high school senior

机译:一名具有免疫能力的高中生用西多福韦治疗腺病毒性肺炎

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Most adenovirus infections are self-limiting in immunocompetent individuals. Here, we report a case of adenovirus pneumonia in a 17-year-old immunocompetent male. He was admitted to our emergency room complaining of a febrile sense, cough, and diarrhea for four days. Crackles in the left lung and a high fever (40.7?°C) were revealed. Initial chest X-ray and computed tomography images showed consolidation in the left lung. We immediately started empirical antibiotic treatment, but his clinical symptoms and pneumonic consolidation in radiography had not improved by hospital day three. Because adenovirus was detected in his sputum using RT-PCR, he was administered Cidofovir. After 24 h of Cidofovir treatment, the symptoms and fever subsided, and the consolidation in his X-ray was significantly reduced by hospital day nine. The early administration of Cidofovir could be beneficial for the treatment of adenovirus infection in immunocompetent patients.
机译:大多数腺病毒感染在具有免疫能力的个体中是自限性的。在这里,我们报告了一名17岁免疫能力强的男性的腺病毒性肺炎病例。他因感觉发热,咳嗽和腹泻四天而进入我们的急诊室。发现左肺有裂痕和高烧(40.7℃)。最初的胸部X射线和计算机断层扫描图像显示左肺巩固。我们立即开始了经验性的抗生素治疗,但是他的临床症状和放射线照相术中的肺炎合并症到第三天医院并没有改善。由于使用RT-PCR在痰液中检测到腺病毒,因此给他服用了西多福韦。西多福韦治疗24小时后,症状和发烧消退,到医院第9天时,他的X线检查中的巩固现象明显减少。早期给予西多福韦可能对治疗免疫功能正常的患者的腺病毒感染有益。

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