• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiation oncology >Multi-scenario based robust intensity-modulated proton therapy (IMPT) plans can account for set-up errors more effectively in terms of normal tissue sparing than planning target volume (PTV) based intensity-modulated photon plans in the head and neck region
【24h】

Multi-scenario based robust intensity-modulated proton therapy (IMPT) plans can account for set-up errors more effectively in terms of normal tissue sparing than planning target volume (PTV) based intensity-modulated photon plans in the head and neck region

机译：与在头颈部区域基于计划目标体积（PTV）的基于强度调制的光子计划相比，基于多场景的鲁棒强度调制的质子治疗（IMPT）计划可以更有效地解决正常组织保留方面的设置错误。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background In a previous report, we compared the conformity of robust intensity-modulated proton therapy (IMPT) plans with that of helical tomotherapy plans for re-irradiations of head and neck carcinomas using a fixed set-up error of 2?mm. Here, we varied the maximum set-up errors between 0 and 5?mm and compared the robust IMPT-plans with planning target volume (PTV) based intensity-modulated photon therapy (IMRT). Findings Seven patients were treated with a PTV-based tomotherapy plan. Set-up margins of 0, 2, and 5?mm were subtracted from the PTV to generate target volumes (TV) TV0mm, TV2mm, and TV5mm, for which robust IMPT-plans were created assuming range uncertainties of ±3.5% and using worst case optimization assuming set-up errors of 0, 2, and 5?mm, respectively. Robust optimization makes use of the feature that set-up errors in beam direction alone do not affect the distal and proximal margin for that beam. With increasing set-up errors, the body volumes that were exposed to a selected minimum dose level between 20% and 95% of the prescribed dose decreased. In IMPT-plans with 0?mm set-up error, the exposed body volumes were on average 6.2%?±?0.9% larger than for IMPT-plans with 2?mm set-up error, independent of the considered dose level (p? Conclusions For recurrent head and neck cancer, robust IMPT-plan optimization led to a decrease in normal tissue exposure with increasing set-up error for target volumes corresponding to the same PTV.
机译：背景技术在先前的报告中，我们比较了固定强度设置为2？mm的鲁棒强度调制质子治疗（IMPT）计划与螺旋层析治疗计划对头和颈癌再照射的符合性。在这里，我们将最大设置误差在0至5？mm之间变化，并将鲁棒的IMPT计划与基于计划目标体积（PTV）的强度调制光子治疗（IMRT）进行了比较。调查结果接受基于PTV的tomotherapy计划治疗了7名患者。从PTV中减去设置边距0、2和5？mm，以生成目标体积（TV）TV 0mm ，TV 2mm 和TV 5mm ，在±3.5％的范围不确定性的情况下创建了鲁棒的IMPT计划，并使用最坏情况的优化分别假设设置误差为0、2和5？mm。强大的优化功能利用了仅在波束方向上的设置误差不会影响该波束的远端和近端边缘的功能。随着设置误差的增加，暴露于规定剂量的20％至95％之间的选定最小剂量水平的人体体积减小。在设定误差为0？mm的IMPT计划中，暴露身体体积平均比设定误差为2？mm的IMPT计划大6.2％？±？0.9％，而与所考虑的剂量水平无关（p结论对于复发性头颈癌，强有力的IMPT计划优化可减少正常组织的暴露，并且对应于相同PTV的目标体积的设置误差会增加。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号