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“Microgravity” as a unique and useful stem cell culture environment for cell-based therapy

机译：“微重力”作为基于细胞的疗法的独特且有用的干细胞培养环境

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摘要

Cell-based therapy using mesenchymal stem cells or pluripotent stem cells such as induced pluripotent stem cells has seen dramatic progress in recent years. Part of cell-based therapy are already covered by public medical insurance. Recently, researchers have attempted to improve therapeutic effects toward various diseases by cell transplantation. Culture environment is considered to be one of the most important factors affecting therapeutic effects, in particular factors such as physical stimuli, because cells have the potential to adapt to their surrounding environment. In this review, we provide an overview of the research on the effects of gravity alteration on cell kinetics such as proliferation or differentiation and on potential therapeutic effects, and we also summarize the remarkable possibilities of the use of microgravity culture in cell-based therapy for various diseases.
机译：近年来，使用间充质干细胞或多能干细胞（例如诱导性多能干细胞）的基于细胞的疗法已取得了显着进展。基于细胞的疗法的一部分已经由公共医疗保险承保。最近，研究人员试图通过细胞移植来改善对各种疾病的治疗效果。培养环境被认为是影响治疗效果的最重要因素之一，尤其是诸如物理刺激之类的因素，因为细胞具有适应周围环境的潜力。在这篇综述中，我们概述了重力改变对细胞动力学（例如增殖或分化）的影响以及对潜在治疗作用的研究，并且我们还总结了在基于细胞的疗法中使用微重力培养的显着可能性各种疾病。

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