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Quantitative analysis of operators’ flow line in the cell culture for controlled manual operation

机译：定量分析细胞培养中操作员的流水线，以控制手动操作

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Introduction Although cell culture has been widely used in the life sciences, there are still many aspects of this technique that are unclear. In this study, we have focused on the manual operations in the cell culture process and try to analyze the operators’ flow line. Methods During a course of approximately 6 years, we obtained the operators’ flow line data from two places (three layouts) and 38 operators (93 subcultures) using two network cameras and a motion detection software (Vitracom SiteView). Results Our investigation succeeded in quantifying the flow line of the subculture process and analyzed the time taken to carry out the process, to travel around the workplace. For the subculture process, the total time of the process being rerated the time of the operation in the place where the main operation is performed; the total distance of travel and the counts of travel not being related to the total time of the process. Based on these results, we propose a new way of evaluating the efficiency of cell culture process in terms of time and traveling. We believe that the results of this study can guide cell culture operators in handling cells more efficiently in cell manufacturing processes. Conclusions The flow line analysis method suggested by us can record the operators involved and improve the efficiency and consistency of the process; it can, therefore, be introduced in cell manufacturing processes. In addition, this method only requires network cameras and motion detection software, which are inexpensive and can be set up easily.
机译：简介尽管细胞培养已在生命科学中广泛使用，但该技术仍有许多方面尚不清楚。在这项研究中，我们将重点放在细胞培养过程中的手动操作上，并尝试分析操作员的生产线。方法在大约6年的时间里，我们使用两个网络摄像机和运动检测软件（Vitracom SiteView）从两个地方（三个布局）和38个操作员（93个亚文化）获得了操作员的流水线数据。结果我们的调查成功地量化了亚培养过程的流线，并分析了进行该过程所需的时间以及在工作场所中的旅行时间。对于继代培养过程，将过程的总时间重新评估为在执行主要操作的地方的操作时间;总行程距离和行程计数与该过程的总时间无关。基于这些结果，我们提出了一种新的方法来评估细胞培养过程在时间和旅行方面的效率。我们相信这项研究的结果可以指导细胞培养操作员在细胞制造过程中更有效地处理细胞。结论我们建议的流线分析方法可以记录所涉及的操作员，并提高过程的效率和一致性。因此，可以将其引入电池制造工艺中。此外，此方法仅需要网络摄像机和运动检测软件，这些设备便宜且易于设置。

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