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首页> 外文期刊>Revista Brasileira de Farmacognosia >Search for cytotoxic agents in multiple Laurencia complex seaweed species (Ceramiales, Rhodophyta) harvested from the Atlantic Ocean with emphasis on the Brazilian State of Espírito Santo
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Search for cytotoxic agents in multiple Laurencia complex seaweed species (Ceramiales, Rhodophyta) harvested from the Atlantic Ocean with emphasis on the Brazilian State of Espírito Santo

机译：在从大西洋中采集到的劳伦西亚复杂海藻物种（Ceramiales，Rhodophyta）中寻找细胞毒剂，重点放在巴西圣埃斯皮里图州

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The development of new anti-cancer drugs of algal origin represents one of the least explored frontiers in medicinal chemistry. In this regard, the diversity of micro- and macroalgae found in Brazilian coastal waters can be viewed as a largely untapped natural resource. In this report, we describe a comparative study on the cytotoxic properties of extracts obtained from the Laurencia complex: Laurencia aldingensis, L. catarinensis, L. dendroidea, L. intricata, L. translucida, L. sp, and Palisada flagellifera. All of these species were collected in the coastal waters of the State of Espírito Santo, Brazil. Four out of the twelve samples initially investigated were found to show significant levels of toxicity towards a model tumor cell line (human uterine sarcoma, MES-SA). The highest levels of cytotoxicity were typically associated with non-polar (hexane) algal extracts, while the lowest levels of cytotoxicity were found with the corresponding polar (methanol) extracts. In this report, we also describe a biological model currently in development that will not only facilitate the search for new anti-cancer drug candidates of algal origin, but also permit the identification of compounds capable of inducing the destruction of multi-drug resistant tumors with greater efficiency than the pharmaceuticals currently in clinical use.
机译：藻类来源的新抗癌药物的开发代表了药物化学中探索最少的领域之一。在这方面，在巴西沿海水域发现的微藻类和大型藻类的多样性可被视为一种尚未开发的自然资源。在此报告中，我们描述了对从Laurencia复合物获得的提取物的细胞毒性特性的比较研究：Laurencia aldingensis，L。catarinensis，L。dendroidea，L。intricata，L。translucida，L。sp和Palisada flagellifera。所有这些物种都收集在巴西圣埃斯皮里图州的沿海水域。发现最初调查的十二个样本中有四个样本对模型肿瘤细胞系（人子宫肉瘤，MES-SA）显示出显着的毒性水平。细胞毒性的最高水平通常与非极性（己烷）藻类提取物有关，而细胞毒性的最低水平与相应的极性（甲醇）提取物有关。在本报告中，我们还描述了目前正在开发的生物学模型，该模型不仅有助于寻找藻类来源的新型抗癌药物，而且还可以鉴定能够诱导破坏多药耐药性肿瘤的化合物。比目前临床上使用的药物效率更高。

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