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首页> 外文期刊>Revista Brasileira de Farmacognosia >Anti-snake venom effect of secodolastane diterpenes isolated from Brazilian marine brown alga Canistrocarpus cervicornis against Lachesis muta venom
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Anti-snake venom effect of secodolastane diterpenes isolated from Brazilian marine brown alga Canistrocarpus cervicornis against Lachesis muta venom

机译：从巴西海洋褐藻Canistrocarpus cervicornis分离得到的仲蛇毒二萜对蛇毒的抗蛇毒作用

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摘要

The effect of a Brazilian algae extract and also a mixture of two secodolastane diterpenes (linearol/isolinearol) that were isolated from the marine brown alga Canistrocarpus cervicornis were evaluated against biological activities of Lachesis muta snake venom. In vitro assays showed that the crude extract and the diterpenes were able to inhibit the clotting and proteolytic activity induced by L. muta crude venom, but not the hemolytic activity. However, only the diterpenes inhibited the hemolysis caused by a purified phospholipase A2 previously isolated from L. muta venom, denoted LM-PLA2-I. Interestingly, the crude algal extract and the diterpenes were able to protect mice from hemorrhage induced by L. muta venom. Thus, we may conclude that marine algae are rich and powerful sources of molecules that may be used against L. muta accidents in order to improve treatment of envenomation by this snake.
机译：评估了巴西藻类提取物以及从海藻褐藻Canistrocarpus cervicornis中分离出的两种secodolastane二萜类化合物（linearol / isolinearol）的混合物对Lachesis muta蛇毒的生物学活性的影响。体外试验表明，粗提物和二萜能够抑制致突变乳杆菌粗毒诱导的凝结和蛋白水解活性，但不能抑制其溶血活性。然而，仅二萜抑制由先前从诱变乳杆菌毒液分离的纯化的磷脂酶A2（称为LM-PLA2-I）引起的溶血。有趣的是，粗藻提取物和二萜能够保护小鼠免受乳杆菌毒液诱导的出血。因此，我们可以得出结论，海藻是丰富而有力的分子来源，可用于抵抗致突变乳杆菌事故，以改善这种蛇对毒液的治疗。

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