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HLA-G histocompatibility antigens related to pregnancy

机译:与妊娠有关的HLA-G组织相容性抗原

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HLA-G component is a class I non-classic molecule (Ib) from the Histocompatibility Principal System, adopting 7 isoforms as result of alternative connection of a same immature ARN; four of them are kinked to membrane (HLA-G1-G2-G3-G4) and the other three forms are soluble (HLA-GG5-G6-G7) with a a1 extracellular common domain. The first ones are expressed in the extravillous cytotrophoblast cells of placenta, epithelial cells of amnion, fetal endothelial cells and mesenchymal macrophages of chorionic villi and in epithelial cells of thymus medulla; and the second ones in amniotic fluid, in maternal peripheral blood and in umbilical cord. During pregnancy, the HLA-G molecules are expressed in an early way in trophoblast cells, maintained during the pregnancy and it is higher in the villous trophoblast. The HLA-G is associated with some complications in gestation, such as intrauterine infections, the pre-eclampsia and the spontaneous recurrent abortion where the HLA-G molecule is useful in pregnancy follow-up.
机译:HLA-G成分是来自组织相容性主要系统的I类非经典分子(Ib),由于同一个未成熟ARN的替代连接而采用7种亚型;它们中的四个扭结到膜上(HLA-G1-G2-G3-G4),其他三种形式是可溶的(HLA-GG5-G6-G7),带有a1个胞外公共结构域。第一个表达于胎盘的绒毛外滋养层细胞,羊膜上皮细胞,绒毛膜绒毛的胎儿内皮细胞和间质巨噬细胞以及胸腺髓质的上皮细胞中。第二种是羊水,孕妇外周血和脐带中的第二种。在怀孕期间,HLA-G分子在滋养层细胞中以较早的方式表达,并在怀孕期间得以维持,而在绒毛滋养层中更高。 HLA-G与妊娠合并症有关,例如子宫内感染,先兆子痫和自然反复流产,其中HLA-G分子可用于妊娠随访。

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