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首页> 外文期刊>Revista Cubana de Hematología, Inmunología y Hemoterapia >Percutaneous implantation of peripheral blood mononuclear cells mobilized with granulocyte colony stimulating factor in osteoarthritis of the knee. First case reported in Cuba
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Percutaneous implantation of peripheral blood mononuclear cells mobilized with granulocyte colony stimulating factor in osteoarthritis of the knee. First case reported in Cuba

机译：粒细胞集落刺激因子动员的外周血单核细胞经皮植入在膝骨关节炎中。古巴报告第一例

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摘要

The degenerative joint disease, also known as osteoarthrosis affects to 10% of elderlies aged 60. It is mainly characterized by pain in the involved joint, crepitation, morning stiff and a progressive limitation of movement of that joint leading to a partial or total wear of articular cartilage. The treatment of the knee osteoarthrosis is a great challenge. The recent advances in use of regenerative medicine suggest that adult stem cells could represent a promisor alternative in the treatment of this entity. In a female patient aged 61 presenting with knee osteoarthrosis authors placed a percutaneous implant of autologous mononuclear cells mobilized to peripheral blood by granulocyte colony-stimulating factor achieving a fast clinical and radiological improvement. This result suggests that the procedure used is a feasible, simple, safe and less expensive method for treatment of articular degenerative lesions.
机译：退化性关节疾病，也称为骨关节炎，影响60％的老年人，占10％。其主要特征是受累关节疼痛，结扎，晨僵和该关节运动的进行性受限，导致关节的部分或全部磨损关节软骨。膝盖骨关节炎的治疗是一个巨大的挑战。再生医学使用的最新进展表明，成体干细胞可能代表了该实体治疗中的有前途的选择。在一名患有膝骨关节炎的61岁女性患者中，作者放置了经粒细胞集落刺激因子动员至外周血的自体单核细胞经皮植入物，从而实现了快速的临床和放射学改善。该结果表明所使用的方法是一种可行的，简单的，安全的且较便宜的方法，用于治疗关节退行性病变。

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