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首页> 外文期刊>Revista Cubana de Hematología, Inmunología y Hemoterapia >Tratamiento de la leucemia mieloide aguda del ni?±o en Cuba
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Tratamiento de la leucemia mieloide aguda del ni?±o en Cuba

机译：在古巴治疗儿童急性髓性白血病

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Introduction. acute myeloid leukemia represents about 20 % of all leukemias in childhood with results and survival smaller than in acute lymphoid leukemia. Objectives: to describe the results obtained with the treatment of acute myeloid leukemia in children in some Cuban centers in from 2000 to 2008. Methods: forty-six patients from Western provinces of Cuba including Sancti Spiritus and Villa Clara were treated. The majority of the patients were males. The median age was 9 years old. Two periods of treatment were applied, the first from 2000 to 2003 with 27 patients; and the second from 2004 to 2008 with 19 cases. The difference between the two periods was that in the second one the consolidation had short and intensive cycles. Results: the initial remission was 71 % in the first period and 89 % in the second. Free survival was 40 % in 5 years and the overall survival (OS) was 44 %, but in the first period the OS was 30,8 % and in the second it was 63,2 %. Immunophenotype and cytogenetic and molecular alterations were studied only in 10 children. Hematopoietic transplantation was not performed sytematically. Conclusions: these results show a level comparable to those achieved internationally, representing a major achievement of the Cuban National Health System.
机译：介绍。急性髓样白血病约占儿童期所有白血病的20％，其结果和生存率均小于急性淋巴白血病。目的：描述2000年至2008年古巴一些中心儿童急性髓细胞白血病的治疗结果。方法：对古巴西部省份Sancti Spiritus和Villa Clara的46例患者进行治疗。大多数患者是男性。中位年龄为9岁。应用了两个阶段的治疗，第一阶段是2000年至2003年，治疗27例患者。第二例是2004年至2008年的19例。这两个时期之间的差异在于，在第二个时期，合并的周期短而密集。结果：第一阶段的初始缓解率为71％，第二阶段为89％。 5年的免费生存率为40％，总生存（OS）为44％，但是在第一阶段，OS为30.8％，在第二阶段为63.2％。仅在10名儿童中研究了免疫表型，细胞遗传学和分子改变。造血移植未按语法进行。结论：这些结果显示了与国际上可比的水平，代表了古巴国家卫生系统的一项重大成就。

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