首页> 外文期刊>Revista Cubana de Hematología, Inmunología y Hemoterapia >Evoluci?3n clonal en la leucemia mieloide cr?3nica
【24h】

Evoluci?3n clonal en la leucemia mieloide cr?3nica

机译:慢性粒细胞白血病的克隆进化

获取原文
           

摘要

Clonal evolution in chronic myeloid leukemia is defined as the presence of a variety of additional, nonrandom chromosomal abnormalities besides the Philadelfia chromosome. It occurs in approximately 30 % of patients in accelerated phase and 80 % of patients in blastic phase. It is considered a criterion for accelerated phase. Although it is associated with a poor prognosis, its significance is controversial. It depends on the specific cytogenetic abnormality, its frequency in karyotype study, the association with other progression clinical and cytogenetic alterations, its relationship with the time of appearance during the course of the disease and the therapy used.
机译:慢性粒细胞白血病的克隆进化被定义为除Philadelfia染色体外还存在多种其他非随机染色体异常。它发生在大约30%的加速期患者和80%的成骨期患者中。它被认为是加速阶段的标准。尽管它与不良预后有关,但其意义尚存争议。它取决于特定的细胞遗传学异常,其在核型研究中的频率,与其他进展的临床和细胞遗传学改变的关联,其与疾病过程中出现时间的关系以及所使用的疗法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号