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Aplicaci?3n de las plaquetas en la extrofia vesical

机译:血小板在膀胱萎缩症中的应用

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Bladder exstrophy is a severe congenital anomaly of lower urinary tract that affects the bladder, pelvic bones, abdominal wall, external genitalia, perineum and in some cases intestine. Conventional treatments are based on surgical techniques, in order to reconstruct bladder, genitals and close wall defect. We present a case of a 3 year old girl, in which surgical treatment was applied 6 times without results. It was decided to combine the surgical treatment with application of regenerative medicine. It was applied platelet lysate in the bladder wall and the edges of the abdominal wall at the rate of 1 mL weekly for 4 weeks, achieving tissue regeneration. It enabled to face the edges of those structures and perform conventional surgical technique. As a result, we achieved a total closure of bladder, urethra and abdominal wall, without fistulas either between these structures or outside. Therefore the use of platelet lysate promotes growth and tissue regeneration comprising the urinary tract, decreasing number of interventions, time exposition structures of the abdominal cavity, and post surgical complications such as fistulas.
机译:膀胱萎缩症是下尿路的一种严重的先天性异常,会影响膀胱,骨盆骨骼,腹壁,外生殖器,会阴部,在某些情况下还会影响肠道。常规治疗基于外科手术技术,以重建膀胱,生殖器和闭合壁缺损。我们介绍了一个3岁女孩的情况,其中进行了6次手术治疗,但未见结果。决定将手术治疗与再生医学相结合。每周以1 mL的速率在膀胱壁和腹壁边缘施以血小板裂解液,持续4周,以实现组织再生。它能够面对那些结构的边缘并执行常规手术技术。结果,我们实现了膀胱,尿道和腹壁的完全闭合,在这些结构之间或外部没有瘘管。因此,血小板裂解物的使用促进了包括尿路的生长和组织再生,减少了干预次数,腹腔的时间暴露结构,以及术后并发症如瘘管。

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