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Trasplante haploid??ntico de progenitores hematopoy??ticos: una necesidad

机译:单倍体造血干细胞移植:必要性

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Hematopoietic stem cell transplantation is a potentially curative therapy for patients with various diseases, but only 25- 30% have a compatible donor for human leukocyte antigen. A few years ago it has been developed a transplant with only one identical haplotype; which it is available for most patients, and has been called haploidentical transplantation. There have been attempts to deplete the marrow of T lymphocytes before being infused, mainly due to the presence graft-versus-host disease, and this can lead to primary graft failure and a slow immune recovery. At present, several methods to overcome these drawbacks are made, so this transplantation emerges as an important alternative for those who do not have a fully matched sibling and has the advantage that allows choosing between several candidates and prevents loss of time searching unrelated donor.
机译:造血干细胞移植对于患有各种疾病的患者是一种潜在的治疗方法,但只有25%到30%的人白细胞抗原具有相容的供体。几年前,已经开发出只有一种相同单倍型的移植物。大多数患者都可以使用,被称为单倍体移植。已经尝试了在输注之前耗尽T淋巴细胞的骨髓,这主要是由于存在移植物抗宿主病,这可能导致原发性移植物衰竭和免疫恢复缓慢。目前,已经采取了几种克服这些缺点的方法,因此对于那些没有完全匹配的兄弟姐妹的人来说,这种移植已成为一种重要的选择,其优点是可以在多个候选者之间进行选择,并且可以避免寻找无关亲戚的时间。

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