• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Revista Brasileira de Farmacognosia >Phytochemical study and antinociceptive effect of the hexanic extract of leaves from Combretum duarteanum and friedelin, a triterpene isolated from the hexanic extract, in orofacial nociceptive protocols
【24h】

Phytochemical study and antinociceptive effect of the hexanic extract of leaves from Combretum duarteanum and friedelin, a triterpene isolated from the hexanic extract, in orofacial nociceptive protocols

机译：孔雀草伤害性协议中杜仲叶和六萜烯（从己酮提取物中分离出的三萜）的叶子己烯提取物的植物化学研究和抗伤害作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Combretum duarteanum Cambess, Combretaceae, is a plant widely distributed in Northeastern Brazil and, in folk medicine, stems and leaves are used for pain treatment. We investigated the antinociceptive effects of the hexanic extract of leaves from C. duarteanum and of friedelin, its main compound, in formalin-, glutamate- and capsaicin- induced orofacial nociception models. In order to isolate friedelin from the hexanic extract, flash chromatography technique was used. Male mice (n = 8/group) were pretreated with hexanic extract, friedelin, morphine or vehicle, before the injection of algogen agents into the right upper lip (perinasal area). The test of formalin-induced orofacial nociception showed that hexanic extract and friedelin significantly reduced nociception (p 0.001) in both phases of testing. In the glutamate and capsaicin-induced orofacial nociception tests, pre-treatment with hexanic extract produced a significant reduction of orofacial nociception (p 0.001) at all doses tested.The results suggest the hexanic extract and friedelin possess antinociceptive effects in models of orofacial nociception in rodents.
机译：Combretaceae的Combretum duarteanum Cambess是一种广泛分布于巴西东北部的植物，在民间医学中，茎和叶用于止痛。我们调查了福尔马林，谷氨酸和辣椒素诱导的口腔伤害感受模型中杜仲叶和己烯二酚的主要成分弗里德林的己酸提取物的抗伤害作用。为了从己酸提取物中分离出弗里德林，使用了快速色谱技术。雄性小鼠（n = 8 /组）用己糖提取物，弗里德林，吗啡或媒介物预处理，然后向右上唇（鼻窦区域）注射促生激素剂。福尔马林引起的口腔痛觉测试表明，己糖提取物和弗里德林在两个测试阶段均显着降低了痛觉感受（p <0.001）。在谷氨酸和辣椒素诱导的口部伤害感受试验中，己酸提取物预处理可在所有测试剂量下均显着降低口部伤害感受（p <0.001），结果表明己酸提取物和弗瑞德林在口部伤害感受模型中具有抗伤害感受作用在啮齿动物中。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号