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首页> 外文期刊>Reviews of Reproduction >On the role of germ cells in mammalian gonad development: quiet passengers or back-seat drivers?
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On the role of germ cells in mammalian gonad development: quiet passengers or back-seat drivers?

机译：关于生殖细胞在哺乳动物性腺发育中的作用：安静的乘客还是后座驾驶员？

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In addition to their role as endocrine organs, the gonads nurture and protect germ cells, and regulate the formation of gametes competent to convey the genome to the following generation. After sex determination, gonadal somatic cells use several known signalling pathways to direct germ cell development. However, the extent to which germ cells communicate back to the soma, the molecular signals they use to do so and the significance of any such signalling remain as open questions. Herein, we review findings arising from the study of gonadal development and function in the absence of germ cells in a range of organisms. Most published studies support the view that germ cells are unimportant for foetal gonadal development in mammals, but later become critical for stabilisation of gonadal function and somatic cell phenotype. However, the lack of consistency in the data, and clear differences between mammals and other vertebrates and invertebrates, suggests that the story may not be so simple and would benefit from more careful analysis using contemporary molecular, cell biology and imaging tools.
机译：除了充当内分泌器官外，性腺还培育和保护生殖细胞，并调节能将基因组传递给下一代的配子的形成。性别确定后，性腺体细胞使用几种已知的信号传导途径来指导生殖细胞的发育。但是，生殖细胞与躯体之间进行通讯的程度，它们用于进行通讯的分子信号以及任何此类信号的重要性仍是悬而未决的问题。本文中，我们回顾了在多种生物中不存在生殖细胞的情况下对性腺发育和功能的研究产生的发现。大多数发表的研究支持以下观点：生殖细胞对于哺乳动物的胎儿性腺发育并不重要，但后来对于稳定性腺功能和体细胞表型变得至关重要。但是，由于数据缺乏一致性，哺乳动物与其他脊椎动物和无脊椎动物之间存在明显差异，这表明故事可能并不那么简单，并且会受益于使用当代分子，细胞生物学和成像工具进行的更仔细的分析。

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