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首页> 外文期刊>Revista Cubana de Hematología, Inmunología y Hemoterapia >Loss of ABH antigenic expression in patients with precancerous and cancerous oral lesions
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Loss of ABH antigenic expression in patients with precancerous and cancerous oral lesions

机译：癌前和癌性口腔病变患者ABH抗原表达的丧失

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摘要

The ABH antigens, which are produced by the interaction of 2 genetic systems, Hh and ABO, are subjected to laws of heredity and may be located not only in the erythrocytes, but also in most of the human cells. The objective of this paper was to investigate the expression of ABH antigens in patients with premalignant and malignant oral lesions. Work was done with samples included in paraffin plugs in patients with oral lesions (n= 57). The patients were classified into 2 groups: a) clinical and anatomopathologically diagnosed premalignant and malignant lesions, and b) benign lesions (n=93). The ABH antigens were investigated by the modified specific immunoadherence technique. Adherence to the vascular tissue was used as a positive control, whereas adherence to the fat tissue was considered as a negative control. The results were semiquantified from strongly positive to negative adherence. A significant relation between the ABH antigen expression and the degree of malignancy of the analyzed lesions (P Yates= 0.005) was observed. The loss of ABH reactivity in the sites of greater tumoral invasiveness is correlated with the tumor development degree, the histological degree and its malignancy.
机译：由两个遗传系统Hh和ABO相互作用产生的ABH抗原受遗传规律的影响，不仅可以位于红细胞中，而且可以位于大多数人细胞中。本文的目的是研究ABH抗原在口腔癌前和恶性病变患者中的表达。对口腔损伤患者（n = 57）的石蜡塞中所含样品进行了研究。将患者分为2组：a）临床和解剖病理学诊断的癌前和恶性病变，b）良性病变（n = 93）。通过改良的特异性免疫粘附技术研究了ABH抗原。对血管组织的粘附被用作阳性对照，而对脂肪组织的粘附被视为阴性对照。结果从强阳性坚持到阴性否定半定量。观察到ABH抗原表达与所分析病灶的恶性程度之间存在显着相关性（P Yates = 0.005）。在具有更大的肿瘤侵袭性的部位中，ABH反应性的丧失与肿瘤的发展程度，组织学程度及其恶性程度相关。

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