Histocompatibility: past, present and future

Macías Abraham Consuelo

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Histocompatibility: past, present and future

机译：组织相容性：过去，现在和未来

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Histocompatibility is the area of Immunology for the study or typing of antigens expressed in the surface of leukocytes, of high polymorfirsm, genetically determined by different allelic variants, implied in organs and tissues reject due to its high level of immunogenicity. The development of Immunology in Cuba since the 1970´s has allowed the gradual introduction of technologies that made it possible to type these antigens and the development of hematopoietic and kidney transplants in our country. The use of molecular biology in this area has made it possible the most precise identification of existing and new antigenic variants previously not known, which have contributed to enlarge new possibilities for hematopoietic transplant to non related donors and with blood cord cells, which increased the options for cure in different diseases.

机译：组织相容性是免疫学领域，用于研究或分型在白细胞表面表达的抗原，具有高度多态性，由不同的等位基因变体遗传决定，暗示器官和组织由于其高水平的免疫原性而被排斥。自1970年代以来，古巴免疫学的发展使得逐步引入使这些抗原得以分型的技术成为可能，并在我国发展了造血和肾脏移植。在这一领域中分子生物学的使用使得最精确地鉴定以前未知的现有和新的抗原变体成为可能，这为扩大向非相关供体和使用脐带血细胞的造血移植提供了新的可能性，这增加了选择的余地用于治疗不同疾病。

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《Revista Cubana de Hematología, Inmunología y Hemoterapia》 |2015年第1期|共页
作者
Macías Abraham Consuelo;
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中图分类病理学;
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Histocompatibility: past, present and future

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