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首页> 外文期刊>Revista Brasileira de Farmacognosia >Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice
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Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice

机译：评价多巴贝替拉诺三醇（一种来自褐藻类粉虱的潜在抗病毒药）对BALB / c小鼠的急性毒性

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摘要

Dolabelladienotriol is a product extracted from the brown marine alga Dictyota pfaffii from Brazil that has been shown to have antiviral activity and low cytotoxicity. Our studies have evaluated the acute toxicity of dolabelladienotriol in BALB/c mice for ten days after administration of a single dose. Among the parameters considered were behavior, weight, biochemical and histological analyses of blood samples taken at three different times (Bs.0, Bs.1 and Bs.2) and optical microscopic examination of organs like liver, kidney, stomach and small intestine. Mice deaths were not observed at any dose during the ten day period. There were some changes in the biochemical analysis results for urea nitrogen (BUN) and alanine aminotransferase (ALT), but the changes were not significantly different from the reference levels of the animals before administration of the substance. Histological analyses of tissues were very similar for all animals. The alterations in liver and kidney tissues did not affect the animals′ behavior at any concentration, not even at 50 mg/kg, where the most significant changes in tissues were seen. This study indicates that dolabelladienotriol has low toxicity in administered dose range.
机译：Dolabelladienotriol是从巴西的棕色海藻Dictyota pfaffii中提取的一种产品，具有抗病毒活性和低细胞毒性。我们的研究已经评估了单次给药后十天多拉美三醇对BALB / c小鼠的急性毒性。所考虑的参数包括在三个不同时间（Bs.0，Bs.1和Bs.2）采集的血样的行为，重量，生化和组织学分析，以及肝，肾，胃和小肠等器官的光学显微镜检查。在十天内未观察到任何剂量的小鼠死亡。尿素氮（BUN）和丙氨酸氨基转移酶（ALT）的生化分析结果有所变化，但变化与施用该物质之前动物的参考水平没有显着差异。所有动物的组织组织学分析都非常相似。肝脏和肾脏组织的变化在任何浓度下都不会影响动物的行为，甚至在50 mg / kg的浓度下也不受影响，在该浓度下，组织的变化最为明显。这项研究表明，多拉贝三醇在给药剂量范围内具有低毒性。

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