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首页> 外文期刊>Revista Brasileira de Psiquiatria >Performance of schizophrenic patients in the Stroop Color Word Test and electrodermal responsiveness after acute administration of cannabidiol (CBD)
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Performance of schizophrenic patients in the Stroop Color Word Test and electrodermal responsiveness after acute administration of cannabidiol (CBD)

机译：急性使用大麻素（CBD）后，精神分裂症患者在Stroop颜色文字测试中的表现和皮肤电反应性

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OBJECTIVE: The last decade has seen increasing evidence of dysfunctions in the endogenous cannabinoid system in schizophrenia and of its relationship with the typical cognitive impairment of the disorder. Studies in animal models, healthy volunteers, and psychotic patients clearly suggest an antipsychotic-like effect of cannabidiol. This study investigated the effects of cannabidiol on selective attention in 28 schizophrenic patients using the Stroop Color Word Test and on these patients' electrodermal responsiveness to auditive stimuli. METHOD: The subjects attended two experimental sessions, the first one without the administration of drugs. In the second session the subjects were divided into three groups that received either a single dose of cannabidiol 300mg or cannabidiol 600mg or placebo. RESULTS: The three groups did not differ significantly with respect to electrodermal measures in the two experimental sessions. When the first and second sessions were compared improved performance was found in all three groups, with patients who received placebo and cannabidiol 300mg performing better than those who received cannabidiol 600mg. CONCLUSION: The single, acute administration of cannabidiol seems to have no beneficial effects on the performance of schizophrenic patients in the Stroop Color Word Test, although the hypothesis that chronic administration may lead to improvement cannot be disregarded.
机译：目的：近十年来，越来越多的证据表明精神分裂症的内源性大麻素系统功能障碍及其与该疾病典型认知障碍的关系。在动物模型，健康志愿者和精神病患者中进行的研究清楚地表明，大麻二酚具有抗精神病样作用。这项研究使用Stroop彩色文字测试研究了大麻二酚对28名精神分裂症患者选择性注意的影响以及这些患者对听觉刺激的皮肤电反应性。方法：受试者参加了两次实验，第一次是不使用药物。在第二阶段中，将受试者分为三组，分别接受单剂量300毫克大麻二酚或600毫克大麻二酚或安慰剂。结果：在两组实验中，三组在皮肤电学测量方面无显着差异。当比较第一和第二阶段时，所有三个组的表现均得到改善，接受安慰剂和300mg大麻二酚的患者的表现优于接受600mg大麻二酚的患者。结论：尽管不能忽视长期服用可能导致病情改善的假设，但在Stroop彩色文字测试中，单次急性服用大麻素对精神分裂症患者的表现似乎没有有益的影响。

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