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首页> 外文期刊>Revista de Cirurgia e Traumatologia Buco-Maxilo-Facial >Diffuse large B-cell lymphfoma EBV-positive in an HIV-positive patient
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Diffuse large B-cell lymphfoma EBV-positive in an HIV-positive patient

机译：HIV阳性患者中弥漫性大B细胞淋巴瘤EBV阳性

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Introduction: Lymphomas infrequently occur in the oral mucosa and are usually associated with immunosuppression provoked by human immunodeficiency virus (HIV). We report here the occurrence of a diffuse large B-cell lymphoma in an immunosuppressed patient (CD4+ T lymphocytes = 153) and emphasize the need for an early differential diagnosis, as well as the importance of a dental surgeon within the context of multiprofessional treatment. Case report: A 51-year-old man reporting discomfort in the right retromolar region and hearing alterations was examined at a stomatology service. Intraoral examination revealed an exophytic and leukoplastic lesion in the region of the ascending mandibular ramus extending to the maxillary tuberosity. An incisional biopsy was indicated and revealed a malignant large round cell neoplasm. An immunohistochemical panel was applied to reach a conclusive diagnosis. Results: The diagnosis of diffuse large B-cell lymphoma was confirmed by immunohistochemical analysis, which revealed positive staining for CD20, CD79a, Ki67, and EBV, as well as morphological findings. The patient was referred to an oncohematologist. Final considerations: The aggressive behavior of the disease, the late diagnosis and severe immunosuppression led to the death of the patient 15 days after the diagnosis.
机译：简介：淋巴瘤很少见于口腔粘膜，通常与人类免疫缺陷病毒（HIV）引起的免疫抑制有关。我们在这里报告了免疫抑制患者（CD4 + T淋巴细胞= 153）中弥漫性大B细胞淋巴瘤的发生，并强调了需要早期鉴别诊断，以及在多专业治疗的背景下牙科医生的重要性。病例报告：在口腔科检查了一名51岁的男子，他报告了右后磨牙区不适和听力改变。口内检查发现，在下颌支的升支区域延伸到上颌结节，有外生性和白细胞病变。进行了切开活检，发现有恶性大圆形细胞瘤。免疫组化专家组进行了结论性诊断。结果：通过免疫组织化学分析证实了弥漫性大B细胞淋巴瘤的诊断，发现CD20，CD79a，Ki67和EBV呈阳性染色，并有形态学发现。病人被转介到肿瘤血液学家。最后考虑：该疾病的侵略行为，晚期诊断和严重的免疫抑制导致患者在诊断后15天死亡。

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