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首页> 外文期刊>Revista de salud animal >Analysis of major surface protein 1a sequence in Cuban isolates of Anaplasma marginale
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Analysis of major surface protein 1a sequence in Cuban isolates of Anaplasma marginale

机译：古巴无缘无核质分离株主要表面蛋白1a序列的分析

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The bovine anaplasmosis is a disease of cattle caused by the rickettsia Anaplasma marginale. The major surface proteins encoded by genes with conserved sequences are potential candidates for vaccines. Among these proteins, MSP1a is expressed by a single copy gene (msp1a). The molecular weight of MSP1a varies among A. marginale isolates from different geographical regions due to the presence, in a variable number, of a sequence of 28-29 amino acids in tandem repeats. In the present study, the sequences of the repeats and of the microsatellite of the protein MSPla of two isolates of A. marginale from bovines in a farm of the Cuban western region were examined. Both isolates belongs to the genotype G, and the isolate 21G presented the repeats T-B-B-C and the 25G of the types T-C. The analysis of these repeated sequences are very important because they include markers for transmissibility by ticks and are of great value for the future development of a vaccine candidate against this hemoparasite.
机译：牛无形体病是由立克次氏体无缘氏菌引起的牛病。具有保守序列的基因编码的主要表面蛋白是疫苗的潜在候选者。在这些蛋白质中，MSP1a由单拷贝基因（msp1a）表达。 MSP1a的分子量在不同地理区域的拟南芥分离株之间有所不同，这是由于串联重复序列中存在28-29个氨基酸序列，数量不等。在本研究中，检查了古巴西部地区一家农场的两个牛缘拟南芥分离物蛋白质MSPla的重复序列和微卫星序列。两种分离物均属于基因型G，分离物21G表现出重复序列T-B-B-C和25G类型的T-C。这些重复序列的分析非常重要，因为它们包括for传播的标记，对于抗这种血液寄生虫的候选疫苗的未来开发具有重大价值。

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