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首页> 外文期刊>Romanian Journal of Biophysics >PROPHYLAXIS AND MITIGATION OF RADIATION-INDUCED CHANGES IN THE ELECTRICAL PROPERTIES OF ERYTHROCYTES BY PALLADIUM LIPOIC ACID NANO-COMPLEX (POLY-MVA)
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PROPHYLAXIS AND MITIGATION OF RADIATION-INDUCED CHANGES IN THE ELECTRICAL PROPERTIES OF ERYTHROCYTES BY PALLADIUM LIPOIC ACID NANO-COMPLEX (POLY-MVA)

机译：钯脂酸纳米复合物（POLY-MVA）对红细胞电学特性的辐射抑制和缓和

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The aim of the present work is to study the prophylactic and mitigation effect of poly-MVA against acute whole body gamma irradiation. Adult male rats were exposed to 6 Gy single dose from Cs-137 source. The electrical properties of erythrocytes suspension were measured in the frequency range 40 kHz to 5 MHz. The lipid peroxidation of liver homogenate, the mean corpuscular volume, hemoglobin concentration and hematocrit were also measured. The animals received daily oral administration of 2 mL/kg body weight of poly-MVA for three different time intervals. The study of the prophylactic effect was applied by two modes of administration: two weeks before irradiation and another group which received continuous administration for two weeks before and two other weeks after irradiation (total time of administration 28 days). The mitigation effect was examined by administration of poly-MVA for two weeks after irradiation. The results showed that exposure to gamma radiation caused a decrease in the AC conductivity, relative permittivity, area under the loss curve and membrane effective capacitance, while caused increase in the lipid peroxidation I day after exposure to radiation. The later change persisted until the 14th day recorded after irradiation. The administration of poly-MVA after irradiation alleviated the radiation-induced damage as appeared from the non-significant change in the measured parameters compared to control. The group which received continuous administration, before and after irradiation, showed better results compared to the group which received administration before irradiation only. The obtained results showed that poly-MVA can be used as prophylactic as well as mitigator agent on planned and accidental radiation exposure.
机译：本工作的目的是研究聚-MVA对急性全身γ射线的预防和缓解作用。成年雄性大鼠暴露于来自Cs-137来源的6 Gy单剂量。在40 kHz至5 MHz的频率范围内测量了红细胞悬液的电性能。还测量了肝脏匀浆的脂质过氧化，平均红细胞体积，血红蛋白浓度和血细胞比容。每天在三个不同的时间间隔内对动物口服口服2 mL / kg体重的poly-MVA。预防作用的研究通过两种给药方式进行：辐射前两周和另一组在辐射前两周和辐射后两周（总给药时间28天）连续给药。通过在照射后两周施用poly-MVA来检查缓解效果。结果表明，暴露于γ射线会导致交流电导率，相对介电常数，损耗曲线下的面积和膜有效电容降低，而导致暴露于辐射后I天的脂质过氧化作用增加。后来的变化一直持续到照射后记录的第14天。辐照后施用聚-MVA减轻了辐射引起的损害，这是由于与对照相比测量参数的无显着变化所致。与仅在放射线之前进行给药的组相比，在放射线之前和之后进行连续给药的组显示出更好的结果。获得的结果表明，聚-MVA可用作计划性和意外辐射暴露的预防和缓解剂。

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