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首页> 外文期刊>Romanian Journal of Biophysics >INTERACTION BETWEEN EPI-GALLO-CATECHIN POLYPHENOL EXTRACTED FROM GREEN TEA AND LIPOSOMES AS A CELL MEMBRANE MODEL
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INTERACTION BETWEEN EPI-GALLO-CATECHIN POLYPHENOL EXTRACTED FROM GREEN TEA AND LIPOSOMES AS A CELL MEMBRANE MODEL

机译：绿茶中提取的EPI-GALLO-儿茶素多酚与脂质体的相互作用作为细胞膜模型

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摘要

Tea has been cultivated for centuries, beginning in India and China. Today, tea is the most widely consumed beverage in the world, second only to water. Hundreds of millions of people drink tea, and studies suggest that green tea (Camellia sinensis) in particular has many health benefits. Green tea is made from unfermented leaves and reportedly contains the highest concentration of powerful antioxidants called polyphenols. Polyphenols exhibit stronger antioxidant protection for human body than vitamin C and vitamin E. Scavenging effect of lipid free-radicals (one antioxidant property) of polyphenols in green tea extracts can be clearly observed in experiments. Many researches addressed polyphenols from the perspective of its antioxidant and anticarcinogenic effect. Despite that many researches has been carried out using different physical techniques, the exact mechanism of interaction between polyphenols’ molecules and membrane lipids is not yet revealed. The aim of work is to investigate, in vitro, the mechanism of interaction between epi-gallo-catechin polyphenols molecules and cell membrane represented by liposomes. The approach of our work is based on 2 phases: first is testing the encapsulation efficiency of liposomes to polyphenols. Second, investigating the structural and phase transition temperature changes for lipid bilayer using FTIR and DSC.
机译：从印度和中国开始，茶栽培已有数百年历史。今天，茶是世界上消费最广泛的饮料，仅次于水。数以亿计的人喝茶，研究表明，绿茶（茶花）尤其具有许多健康益处。绿茶是由未发酵的叶子制成的，据报道含有浓度最高的强效抗氧化剂，称为多酚。多酚比维生素C和维生素E对人体具有更强的抗氧化保护作用。在实验中可以清楚地观察到绿茶提取物中多酚对脂质自由基的清除作用（一种抗氧化特性）。许多研究都从多酚的抗氧化和抗癌作用出发。尽管已使用不同的物理技术进行了许多研究，但多酚分子与膜脂之间相互作用的确切机理尚未揭示。工作的目的是在体外研究表没食子儿茶素多酚分子与脂质体代表的细胞膜之间相互作用的机制。我们的工作方法基于两个阶段：首先是测试脂质体对多酚的包封效率。其次，使用FTIR和DSC研究脂质双层的结构和相变温度变化。

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