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SOLAR RADIATION AND SKIN CANCER RISK – BIOPHYSICAL INSIGHTS

机译:太阳辐射和皮肤癌风险–生物物理学的见解

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摘要

Solar radiation is the main environmental risk factor for skin cancer, whose incidence is rapidly increasing in the last decades. Individuals carry different skin cancer risk, depending mainly on the skin color (melanin type and distribution) and therefore Fitzpatrick skin typing is a widely used method to predict skin cancer risk. However, this method has its limitations as other factors are involved in skin cancer susceptibility, like genetic factors (MC1R variants) or DNA damage repair mechanisms. Thus, there is an urgent need for implementing objective, non-invasive methods to assess skin sensitivity and reactivity to sun exposure. In this review, I will analyze the main factors involved in photoprotection and the new devices currently employed to evaluate the response to ultraviolet radiation (in terms of erythema and pigmentation) and thus to predict skin cancer risk.
机译:太阳辐射是皮肤癌的主要环境危险因素,在过去的几十年中,其发病率迅速增加。个体承担不同的皮肤癌风险,主要取决于肤色(黑色素类型和分布),因此Fitzpatrick皮肤分型是预测皮肤癌风险的一种广泛使用的方法。但是,这种方法有其局限性,因为其他因素也参与了皮肤癌的易感性,例如遗传因素(MC1R变体)或DNA损伤修复机制。因此,迫切需要实施客观的,非侵入性的方法来评估皮肤的敏感性和对日晒的反应性。在这篇综述中,我将分析与光保护有关的主要因素以及目前用于评估对紫外线辐射(红​​斑和色素沉着)的新设备,从而预测皮肤癌的风险。

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