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COMPUTATIONAL STUDY OF CYTOSINE INTERACTION WITH UV LIGHT

机译:胞嘧啶与紫外线相互作用的计算研究

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DNA interaction with UV radiation is an actual problem for medicine and biology, as prolonged sun exposure is the cause for the majority of skin cancers. This paper is focused on the computational modeling of UV light interaction with cytosine nucleotide by applying quantum chemical approach based on semi-empirical method. The comparison of some energetic and structural parameters of cytosine nucleotide and its two derivatives resulted following UV radiation absorption has evidenced the linear dependence of dipole moment and total energy as provided by optimized structure analysis.
机译:DNA与紫外线辐射的相互作用是医学和生物学领域的实际问题,因为长时间暴露在阳光下是大多数皮肤癌的原因。本文采用基于半经验方法的量子化学方法,重点研究了紫外光与胞嘧啶核苷酸相互作用的计算模型。通过对紫外线辐射吸收后胞嘧啶核苷酸及其两个衍生物的一些能量和结构参数的比较,证明了优化结构分析提供的偶极矩和总能量的线性相关性。

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