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首页> 外文期刊>Romanian Journal of Biophysics >EVALUATION OF RADIOPROTECTIVE EFFECTS OF SOME BEE PRODUCTS AND ITS FLAVONOID CONSTITUENTS: IN VIVO STUDY ON MALE RATS
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EVALUATION OF RADIOPROTECTIVE EFFECTS OF SOME BEE PRODUCTS AND ITS FLAVONOID CONSTITUENTS: IN VIVO STUDY ON MALE RATS

机译：某些蜂产品及其类黄酮成分的放射防护效果评估：对成年大鼠的体内研究

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Radioprotection with natural products may be relevant to the mitigation of ionizing radiation-induced damage in mammalian systems. This study was designed to investigate antioxidant activity of honey and propolis in vitro through determination of total phenol (TP), total flavonoid (TF) and free radical scavenging activity (RSA). In addition to, in an in vivo study, male rats were exposed to fractionated dose gamma irradiation (1 Gy every day up to 5 Gy total doses). Honey and propolis administrated at dose 250 and 90 mg?kg–1?day–1. The serum levels of alanine transaminase (ALT) and aspartate transaminase (AST), urea, creatinine and total antioxidants capacity was estimated. Also hemoglobin of rats was investigated through UV absorption spectrum and dielectric measurements. The results indicated that total flavonoid, total phenol and free radical scavenging activity of propolis were greater than honey. AST, ALT, creatinine and urea significantly increased while total antioxidants significantly decreased after irradiation. Moreover the absolute values of permittivity ?', dielectric loss ?'' and ac-conductivity ?ac increased in addition to a pronounced decrease in the absorbance at Soret band after irradiation compared to control group. Administration of propolis induced a significant recovery of antioxidant balance in rats exposed to ionizing radiation. Indeed, decrease of AST, ALT, creatinine and urea levels decreased in these animals while total antioxidants significantly increased. Also, the values of ?', ?'' and ?ac were nearly close to those of control group compared to those treated with honey. Finally, the average value of peak height of Soret band was significantly increased compared to irradiated rat. It can be concluded that propolis can be more effective than honey in the protection against oxidative damage induced by ionizing radiation. Further investigations are required to elucidate mechanisms of propolis and honey actions.
机译：天然产物的辐射防护可能与减轻哺乳动物系统中电离辐射引起的损害有关。本研究旨在通过测定总酚（TP），总黄酮（TF）和自由基清除活性（RSA）来研究蜂蜜和蜂胶的体外抗氧化活性。此外，在一项体内研究中，雄性大鼠接受了分次剂量的伽马射线辐照（每天1 Gy，每天总剂量5 Gy）。蜂蜜和蜂胶的剂量为250和90 mg？kg–1？天–1。评估了血清丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST），尿素，肌酐和总抗氧化剂的水平。还通过紫外线吸收光谱和介电测量研究了大鼠的血红蛋白。结果表明蜂胶的总黄酮，总酚和自由基清除活性均大于蜂蜜。放射后，AST，ALT，肌酐和尿素显着增加，而总抗氧化剂显着减少。此外，与对照组相比，除了辐照后在Soret带的吸光度显着降低之外，介电常数α'，介电损耗α”和交流电导率αac的绝对值均增加。施用蜂胶可在暴露于电离辐射的大鼠体内显着恢复抗氧化剂平衡。确实，这些动物体内AST，ALT，肌酐和尿素水平的降低已降低，而总抗氧化剂却显着增加。另外，与用蜂蜜处理的那些相比，α′，β”和αac的值几乎接近于对照组的值。最后，与辐照大鼠相比，Soret谱带峰高的平均值显着增加。可以得出结论，蜂胶在防止电离辐射引起的氧化损伤方面比蜂蜜更有效。需要进一步研究以阐明蜂胶和蜂蜜的作用机理。

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