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首页> 外文期刊>Romanian Journal of Biophysics >SELECTIVE DETERMINATION OF DOPAMINE USING MODIFIED ELECTRODES BY DIFFERENTIAL PULSE VOLTAMMETRY
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SELECTIVE DETERMINATION OF DOPAMINE USING MODIFIED ELECTRODES BY DIFFERENTIAL PULSE VOLTAMMETRY

机译：差动脉冲伏安法选择性地测定修饰电极中的多巴胺

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摘要

Selective detection of dopamine (DA) shows physiological and pathological importance because DA was widely accepted as one of the most important neurotransmitters involved in physiological processes in the mammalian central nervous system and as a prognostic biomarker for many types of diseases. In this paper a highly sensitive electrochemical method for selective determination of DA in the presence of ascorbic acid (AA), one of the most potentially interferent coexisting in the cerebral systems, is investigated. Chemically modified gold electrodes with thin layers of cobalt (II)-porphyrins (CoP) were used and characterized for DA and AA selective preconcentration and detection. The presence of CoP was favorable for the affinity adsorption of DA. This led to the decrease in the oxidation potential of AA and the enhanced oxidation peak currents of DA at the CoP-modified Au electrode. By differential pulse voltammetry (DPV), the oxidation potentials of DA and AA, at the CoP-modified Au electrode in a binary mixture were found to be well resolved so their simultaneous determination could be achieved. Under the optimized experimental conditions in DPV technique both DA and AA reveal sensitive oxidation peaks for micromolar range of concentrations.
机译：多巴胺（DA）的选择性检测显示出生理和病理学的重要性，因为DA被公认为是哺乳动物中枢神经系统中参与生理过程的最重要的神经递质之一，并作为多种疾病的预后生物标志物。本文研究了一种高灵敏度的电化学方法，用于在抗坏血酸（AA）存在下选择性测定DA，抗坏血酸是大脑系统中最可能共存的干扰物之一。化学修饰的金电极具有钴（II）-卟啉（CoP）薄层，并用于DA和AA的选择性预浓缩和检测。 CoP的存在有利于DA的亲和吸附。这导致在CoP修饰的Au电极上，AA的氧化电位降低，而DA的氧化峰值电流增加。通过差分脉冲伏安法（DPV），发现二元混合物中CoP修饰的Au电极上DA和AA的氧化电位得到了很好的分辨，因此可以同时测定。在DPV技术的最佳实验条件下，DA和AA均显示出微摩尔浓度范围内的敏感氧化峰。

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