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首页> 外文期刊>Romanian Journal of Biophysics >INTERACTION OF BISOPROLOL OR ENALAPRIL WITH DISTEAROYL PHOSPHATIDYL CHOLIN LIPOSOMES: FTIR AND DSC STUDIES
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INTERACTION OF BISOPROLOL OR ENALAPRIL WITH DISTEAROYL PHOSPHATIDYL CHOLIN LIPOSOMES: FTIR AND DSC STUDIES

机译：双酚或纳那普利与二硬脂酰磷脂酰胆碱脂质体的相互作用：FTIR和DSC研究

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The biophysical interactions of bisoprolol or enalapril with distearoyl phosphotidylcholine (DSPC) multilamellar liposomes were investigated by using two non-invasive techniques of Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC). DSC showed that the mixtures of DSPC and bisoprolol or enalapril show a single peak, which indicates that they are miscible. The incorporated bisoprolol or enalapril is probably associated and interacted to large extent with the lipid bilayers that perturbed them which results in the strong broadening and shift to lower temperature 69 °C and 61 °C, respectively of the major characteristic endothermic peak of pure DSPC that exists at 102 °C. The pretransition of liposomes was eliminated for all samples containing bisoprolol or enalapril. Analysis of C=O stretching bond in FTIR spectroscopy showed that bisoprolol or enalapril does not make any hydrogen bonds with the interfacial region of DSPC liposomes, instead it induces free carbonyl groups in the system. These results revealed that enalapril or bisoprolol was located in the interfacial region of the membrane. The studies with model membranes could provide a rational approach for drug discovery and development as well as for developing efficient drug delivery systems.
机译：通过使用傅立叶变换红外（FTIR）光谱和差示扫描量热法（DSC）的两种非侵入性技术，研究了比索洛尔或依那普利与二硬脂酰磷脂酰胆碱（DSPC）多层脂质体的生物物理相互作用。 DSC显示DSPC和比索洛尔或依那普利的混合物显示一个峰，表明它们是可混溶的。掺入的比索洛尔或依那普利可能与干扰它们的脂质双层相关联并在很大程度上相互作用，从而导致纯DSPC的主要特征吸热峰分别强烈扩散并转移至较低的温度69°C和61°C。存在于102°C。对于所有含有比索洛尔或依那普利的样品，都消除了脂质体的预转化。 FTIR光谱中C = O拉伸键的分析表明，比索洛尔或依那普利不会与DSPC脂质体的界面区域形成任何氢键，而是会诱导系统中的游离羰基。这些结果表明，依那普利或比索洛尔位于膜的界面区域。用模型膜进行的研究可以为药物发现和开发以及开发有效的药物输送系统提供合理的方法。

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