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THE EFFECT OF LIPID BILAYER HYDRATION ON TRANSBILAYER PORES APPEARANCE

机译:脂质双层水合对跨膜孔外观的影响

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In this work we have determined the parameters of transbilayer pore formation induced by the collective thermal motion (CTM) of phospholipid bilayer molecules. Using the general theory of continuous elastic media we have designed a simple model of pore formation. The pore radius calculus describes in mathematical terms the lipid bilayer fluctuations, which give rise to different types of pores: open stable pores, closed stable pores (zippered pores) and unstable open pores (which determine the membrane breakdown). After bilayer deformation, the sinusoidal torus becomes an elliptical torus. Equating the volumes of these geometrical shapes, we obtain the mathematical expression of the pore radius. Comparing the pore radius with the hydrophobic bilayer thickness, the pore stability can be estimated. The effect of different degrees of polar groups hydration on the thermoporation process was analyzed.
机译:在这项工作中,我们确定了由磷脂双层分子的集体热运动(CTM)引起的跨双层孔形成的参数。使用连续弹性介质的一般理论,我们设计了一个简单的孔形成模型。孔半径演算用数学术语描述了脂质双层起伏,其引起不同类型的孔:开放的稳定孔,封闭的稳定孔(拉链孔)和不稳定的开放孔(确定膜破裂)。双层变形后,正弦环形面变为椭圆形环形面。等同于这些几何形状的体积,我们可以获得孔半径的数学表达式。将孔半径与疏水性双层厚度进行比较,可以估计孔的稳定性。分析了不同程度的极性基团水合对热穿孔过程的影响。

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