INVESTIGATION OF THE INTERACTION BETWEEN NAPROXEN AND HUMAN SERUM ALBUMIN

A. P?RN?U; M. BOGDAN

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INVESTIGATION OF THE INTERACTION BETWEEN NAPROXEN AND HUMAN SERUM ALBUMIN

机译：萘普生与人血清白蛋白相互作用的研究

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Human serum albumin (HSA), is the principal extracellular protein with a high concentration in blood plasma and carrier for many drugs to different molecular targets. This work was designed to examine the interaction of human serum albumin (HSA) with naproxen (NAP) in aqueous solution, using constant protein concentration of 1.25 μM and various naproxen contents of 4 –200 μM. UV-vis spectroscopy was used to determine the binding mode. The binding constant and the number of the binding sites were obtained using an identical independent-binding sites model, which assumes that each HSA molecule has n low-affinity binding sites, each with the same binding constant Kd.

机译：人血清白蛋白（HSA）是血浆中的主要细胞外蛋白，在多种药物中具有很高的浓度，并且是许多针对不同分子靶标的药物的载体。这项工作旨在使用恒定的1.25μM蛋白质浓度和4–200μM的各种萘普生含量检查水溶液中人血清白蛋白（HSA）与萘普生（NAP）的相互作用。使用紫外可见光谱法确定结合模式。使用相同的独立结合位点模型获得结合常数和结合位点数，该模型假设每个HSA分子具有n个低亲和力结合位点，每个结合位点Kd均相同。

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《Romanian Journal of Biophysics》 |2008年第1期|共7页
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A. P?RN?U; M. BOGDAN;
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INVESTIGATION OF THE INTERACTION BETWEEN NAPROXEN AND HUMAN SERUM ALBUMIN

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