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A STUDY ON PORE FORMATION DYNAMICS IN BIO-MIMICKING MEMBRANE SYSTEM

机译:仿生膜系统成孔动力学研究

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Transmembrane electrical activities are modulated due to the presence of membrane embedded pores and channels. We have studied the role of lipid membrane which mimics the biological membrane and plays an important role in charge conduction mechanism through membrane. Electrical currents, arising from conduction of ions or charges through field induced pores, fluctuate due to its own dynamics. We have performed statistical analysis on this current fluctuation data under different voltage clamp conditions. The result shows that after a certain cut off value the probability distribution of current fluctuation values follow a power law up to a certain range. Additionally the power law of magnitude of large fluctuations indicates the scale-invariance of size of pores and power law of first time return probability indicates that the dynamical behaviour during transport through pores is correlated and the underlying dynamics during the conduction through pores is analogous to the ion channel dynamics
机译:跨膜电活动由于存在膜嵌入的孔和通道而受到调节。我们已经研究了脂质膜的作用,该膜模仿生物膜并在通过膜的电荷传导机制中起重要作用。离子或电荷通过电场感应的孔传导而产生的电流由于其自身的动力学而波动。我们对不同电压钳位条件下的电流波动数据进行了统计分析。结果表明,在某个截止值之后,电流波动值的概率分布在一定范围内遵循幂定律。另外,大波动幅度的幂定律表明孔的大小尺度不变,首次返回概率的幂定律表明通过孔传输过程中的动力学行为是相关的,并且在通过孔传导过程中的基本动力学类似于离子通道动力学

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