首页> 外文期刊>Romanian Journal of Biophysics >THE EFFECTS OF EPIGALLOCATECHIN GALLATE ON ARTIFICIAL LIPID MEMBRANES
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THE EFFECTS OF EPIGALLOCATECHIN GALLATE ON ARTIFICIAL LIPID MEMBRANES

机译:没食子儿茶素没食子酸没食子酸酯对人工脂膜的影响

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Epigallocatechin-3-gallate (EGCG) a natural antioxidant, belonging to the family of catechins, revealed itself as a potent drug having multiple medical applications. In order to better understand the mechanisms underlying its action at the cellular level, we have studied the modifications induced by EGCG on the electric properties, i.e. capacitance and conductance, of artificial lipid membranes, by means of the electrophysiological method Black Lipid Membrane (BLM). While the electrical conductance of the lipid bilayer has been not affected by EGCG in the concentration range studied, its capacitance evolved in a concentration dependent manner. Our results suggested a complex mechanism of insertion of EGCG in the lipid membrane.
机译:表儿茶素-3-没食子酸酯(EGCG)是一种天然抗氧化剂,属于儿茶素家族,它本身显示为具有多种医疗用途的有效药物。为了更好地了解其在细胞水平上作用的机制,我们已经通过电生理方法黑脂膜(BLM)研究了EGCG诱导的对人工脂质膜的电特性(即电容和电导)的修饰。 。虽然在所研究的浓度范围内,脂质双层的电导率不受EGCG的影响,但其电容量以浓度依赖性的方式演变。我们的结果表明,EGCG在脂质膜中插入的复杂机制。

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