Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome

Kouam Foubi Brice Bertrand; Chuisseu Djamen Dieudonne Pascal; Dzeufiet Djomeni Paul Desire; Samba Ngano Odette; Mouelle Sone; Ongolo Zogo Pierre; Dong A Zok Faustin; Yomi Jean; Juimo Alain George; Nkoo Amvene Samuel; Tiedeu Alain Bertin; Gonsu Fotsin Joseph

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Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome

机译：老蒜提取物对急性放射综合征后前驱期的影响

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Acute radiation syndrome results in 4 four phases among which the prodromal one characterized by malaise, diarrhea, vomiting, and anorexia. It last a few hours, but from irradiation to the 7th day after, some other signs (unspecified, mild, moderate or severe) are observed. Thus, the aim of this study was to assess if Aged garlic extract (AGE) could offer radioprotection by preventing signs of prodromal phase after acute radiation syndrome. Knowing, AGE is a natural product containing different compounds with antioxidant activity and possessing several physiological activities in experimental animals. Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoic Acid. The signs observed and evaluated (behavioral changes, salivation, state stool, water and food intake, weight loss, relative weight of organs, fatigue/weakness, temperature and bleeding) revealed a significant change in irradiated groups although AGE-pretreated rats prior and after irradiation revealed significant amelioration in radiation-induced disturbances. Therefore AGE can be considered having radioprotective effects against radiation-induced changes in prodromal phase signs.

机译：急性放射综合症分为四个四个阶段，其中前驱阶段以不适，腹泻，呕吐和厌食为特征。它持续几个小时，但是从辐照到术后第7天，还观察到其他一些症状（未指明，轻度，中度或严重）。因此，本研究的目的是评估老化的大蒜提取物（AGE）是否可以通过预防急性放射综合症后前驱期的体征提供辐射防护。众所周知，AGE是一种天然产品，包含具有抗氧化活性的不同化合物，并在实验动物中具有多种生理活性。分为八组，每组五只健康的雄性大鼠（分别照射20只和20只假鼠），其中一些通过管饲蒸馏水接受，其他以不同剂量（25 mg / kg和50 mg / kg）的AGE服用，其余维生素E +硫辛酸。观察和评估的体征（行为变化，唾液分泌，状态大便，水和食物摄入，体重减轻，器官相对重量，疲劳/虚弱，温度和出血）显示，尽管AGE预处理的大鼠前后，辐照组均发生了显着变化。辐射显示辐射引起的干扰明显改善。因此，AGE可以被认为具有对辐射诱导的前驱期体征变化的放射防护作用。

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《Nuclear Science》 |2016年第1期|共12页
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Kouam Foubi Brice Bertrand; Chuisseu Djamen Dieudonne Pascal; Dzeufiet Djomeni Paul Desire; Samba Ngano Odette; Mouelle Sone; Ongolo Zogo Pierre; Dong A Zok Faustin; Yomi Jean; Juimo Alain George; Nkoo Amvene Samuel; Tiedeu Alain Bertin; Gonsu Fotsin Joseph;
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1. Protective Effect of Aged Garlic Extract Against the Oxidative Stress Induced by Acute Ionizing Irradiation on Hepatic Antioxidant Enzymes in Rats [J] . Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonne Pascal, Dzeufiet Djomeni Paul Desire, European Journal of Clinical and Biomedical Sciences . 2016,第6期

机译：大蒜提取液对急性电离辐射诱导的大鼠肝脏抗氧化酶氧化应激的保护作用。
2. The Study of the Radiation Protection of Aged Garlic Extract to the Radiation Effects in Male Rat’s Sperm [J] . Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, International Journal of Biochemistry, Biophysics & Molecular Biology . 2016,第2期

机译：大蒜提取物对雄性大鼠精子的辐射防护作用的研究
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机译：老化的红蒜提取物可降低血脂多糖诱导的RAW 264.7巨噬细胞中一氧化氮的产生以及通过血红素加氧酶-1的诱导而引起的急性肺部炎症
4. Antioxidants in Processed Garlic: Tetrahydro-β-carboline Derivatives in Aged Garlic Extract [C] . Nagatoshi Ide, Makoto Ichikawa, Kenjiro Ryu, Symposium on food factors in health promotion and disease prevention . 2003

机译：加工大蒜中的抗氧化剂：老年大蒜提取物中的四氢-β-咔啉衍生物
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机译：兔子中的急性辐射低血压：人类辐射休克综合征的模型。
6. Safety and efficacy of aged garlic extract in dogs: upregulation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway and Nrf2-regulated phase II antioxidant enzymes [O] . Osamu Yamato, Tadamitsu Tsuneyoshi, Mitsuyasu Ushijima, 2018

机译：老年大蒜提取物在狗中的安全性和有效性：核因子红系2相关因子2（Nrf2）信号通路和Nrf2调控的II期抗氧化酶的上调
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机译：急性放射性疾病：前驱综合症，注释书目。

Effect of Aged Garlic Extract on Prodromal Phase After Acute Radiation Syndrome

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