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首页> 外文期刊>Occupational Diseases and Environmental Medicine >Regular Observation of De-Acclimatization and Randomized Controlled Research of Diagnostic Criteria of High Altitude De-Acclimatization Syndrome among Different Plateau Migrants Crowd after Their Return to the Plain
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Regular Observation of De-Acclimatization and Randomized Controlled Research of Diagnostic Criteria of High Altitude De-Acclimatization Syndrome among Different Plateau Migrants Crowd after Their Return to the Plain

机译：高原迁徙人群回归平原后的除湿常规观察和高海拔除湿综合症诊断标准的随机对照研究

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Objective: The objective of this study was to investigate the diagnostic methods of high altitude de-acclimatization syndrome and to formulate diagnostic criteria. Methods: This study was conducted using epidemiological surveys and a multi-center randomized controlled clinical trial. A total of 3011 subjects were studied, and the following indices were collected after their return to low altitude areas from the plateau: general health status, blood, urine and stool samples, myo-cardial enzyme levels, liver and kidney function, nerve function, sex hormone levels, microalbuminuria, electrocardiogram (ECG), echocardiography, pulmonary function, and hemorheological markers. These data were compared to those of randomized healthy subjects in the same age range who lived at the same altitude to determine the characteristics of high altitude de-acclimatization syndrome. Based on these characteristics, diagnostic criteria for high altitude de-acclimatization syndrome were formulated. Results: This study demonstrated that the incidence of high altitude de-acclimatization syndrome was 84.36%. Sixty percent of the cases were mild, 30% were medium, and 10% were severe. The incidence was higher among those who returned to a place of lower altitude, resided at a high altitude for a longer period of time, or engaged in heavy labor while at high altitude. Patients with high altitude de-acclimatization syndrome manifested hematological abnormalities and abnormal ventricular function, notably a right ventricular diastolic function, which recovered to baseline function after one to five years. Exposure to long-term hypoxia often caused obvious changes in cardiac morphology, i.e., left and right ventricular hypertrophy, particularly within the right ventricle. In addition, patients with high altitude de-acclimatization syndrome often presented with low blood pressure, low pulse pressure, and microalbuminuria. A few patients presented with occult blood in their feces. The diagnosis of high altitude de-acclimatization syndrome can be made if a patient who recently returns to the plain from the plateau complains of dizziness, weakness, sleepiness, chest tightness, edema, memory loss, and other symptoms and signs that do not alleviate under short-term rehabilitation or symptomatic treatment, and if organic diseases of the heart, lung, kidney, and other organs have been excluded. Conclusion: The diagnosis of high altitude de-acclimatization syndrome should be made after a comprehensive analysis of the patient’s clinical symptoms and signs.
机译：目的：本研究的目的是研究高海拔去适应综合征的诊断方法并制定诊断标准。方法：本研究是使用流行病学调查和多中心随机对照临床试验进行的。共研究了3011名受试者，他们从高原返回低海拔地区后收集了以下指标：总体健康状况，血液，尿液和粪便样本，心肌酶水平，肝肾功能，神经功能，性激素水平，微量白蛋白尿，心电图（ECG），超声心动图，肺功能和血液流变学指标。将这些数据与在相同年龄范围内生活在相同海拔的随机健康受试者的数据进行比较，以确定高海拔去适应综合征的特征。基于这些特征，制定了高海拔去适应综合征的诊断标准。结果：这项研究表明，高海拔去适应综合征的发生率为84.36％。轻度病例占60％，中度病例占30％，重度病例占10％。那些返回低海拔地区，在高海拔地区居住较长时间或在高海拔地区从事繁重劳动的人中，发病率较高。高海拔去适应综合征的患者表现出血液学异常和心室功能异常，特别是右心室舒张功能，在1至5年后恢复到基线功能。长期缺氧通常会引起心脏形态的明显变化，即左，右心室肥大，尤其是在右心室内。另外，患有高海拔去适应综合征的患者经常表现出低血压，低脉压和微量白蛋白尿。少数患者的粪便中有隐血。如果最近从高原返回平原的患者抱怨出现头晕，虚弱，嗜睡，胸闷，水肿，记忆力减退以及其他症状和体征不能缓解，则可以诊断为高原脱适应综合征。短期康复或对症治疗，以及是否排除了心脏，肺，肾和其他器官的器质性疾病。结论：应综合分析患者的临床症状和体征，才能诊断出高海拔去适应综合征。

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