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首页> 外文期刊>Occupational Diseases and Environmental Medicine >Is Exposure to Titanium Dioxide Nanoparticle Associated with Occupational Lung Cancer among Titanium Dioxide Production Workers? An Emerging Issue
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Is Exposure to Titanium Dioxide Nanoparticle Associated with Occupational Lung Cancer among Titanium Dioxide Production Workers? An Emerging Issue

机译：二氧化钛生产工人中与职业性肺癌相关的二氧化钛纳米颗粒的暴露吗？新兴问题

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This systemic literature review was conducted to find out if there was an association between exposure to TiO_(2) NP (Titanium dioxide nanoparticle) and occupational lung cancer among TiO_(2) production workers. An electronic database search was employed which generated several studies relating to TiO_(2) nanoparticle toxicity. From these studies only ten (10) articles were chosen for this study because they met the review criteria. Two articles were centered around cohort study design while other 8 studies were on experimental design. The two cohort studies did answer the review question that showed no association of TiO_(2) toxicity and respiratory diseases while the experimental design studies produced conflicting results. The conflicting results were attributed to their objective, sample size, and the study designs. Despite the different conclusions there is adequate evidence in the experimental studies that demonstrated evidence of TiO_(2) nanoparticle toxicity. Notable cases include cytotoxicity, genotoxicity, apoptotic and cell necrosis in rat and human cells exposed to TiO_(2) which is generally dose response related. The strengths and limitations of the 10 studies are also discussed. General understanding gained from these studies is for appropriate agencies to be proactive in developing mitigation and controls measures against nanoparticle exposure. This is necessary to avert repetition of previous experiences with exposure to asbestos fibers as a point of reference.
机译：进行了系统的文献综述，以了解在TiO_（2）生产工人中暴露于TiO_（2）NP（二氧化钛纳米颗粒）与职业性肺癌之间是否存在关联。使用了电子数据库搜索，该搜索生成了与TiO_（2）纳米颗粒毒性有关的数项研究。从这些研究中，只有十（10）篇文章被选为这项研究，因为它们符合审查标准。有两篇文章以同类研究设计为中心，而其他八篇研究则是关于实验设计的。两项队列研究确实回答了审查问题，该问题表明TiO_（2）毒性与呼吸系统疾病无关联，而实验设计研究产生了矛盾的结果。矛盾的结果归因于其目标，样本量和研究设计。尽管得出不同的结论，但是在实验研究中有足够的证据表明TiO_（2）纳米颗粒具有毒性。值得注意的情况包括暴露于TiO_（2）的大鼠和人类细胞中的细胞毒性，基因毒性，凋亡和细胞坏死，这通常与剂量反应有关。还讨论了这10项研究的优缺点。从这些研究中获得的一般理解是，适当的机构应积极制定缓解措施并控制针对纳米粒子暴露的措施。为了避免重复以前接触石棉纤维的经验，这是必要的。

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