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首页> 外文期刊>Oncología >Post transplantation human herpes virus-8 unrelated primary effusion lymphoma of the peritoneal cavity in a HIV-negative female
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Post transplantation human herpes virus-8 unrelated primary effusion lymphoma of the peritoneal cavity in a HIV-negative female

机译：HIV阴性女性的移植后人类疱疹病毒8无关腹膜腔积液淋巴瘤

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摘要

Primary effusion lymphoma (PEL) is a recently individualized form of non-Hodgkin lymphoma (WHO classification), developing mainly in HIV-infected males, more frequently homosexual, in advanced stages of the disease (total CD4+ lymphocyte count below 100-200/μl). Occasionally, it appears in other immunosupressive states (such as solid organs transplantation period) and even, although very rarely, in immunocompetent patients. From a pathogenic point of view, PEL has been related to Kaposi's sarcoma associated herpes virus (also named human herpesvirus 8, HHV 8) and to clinical antecedents of Kaposi's sarcoma. The relatively low frequency of this disease, the absence of a wide casuisticsts allowing a better characterization, and its unfavourable outcome, support the need of a deeper knowledge. We present here the clinico-biological findings of a HIV-negative patient, who was diagnosed of peritoneal PEL, of T cell origin, and not HHV 8-associated, five years after renal transplantation.
机译：原发性渗出性淋巴瘤（PEL）是非霍奇金淋巴瘤的一种新近个体化形式（WHO分类），主要在该疾病的晚期阶段感染HIV的男性（更常见是同性恋）中发展（CD4 +淋巴细胞总数低于100-200 /μl） ）。有时，它会以其他免疫抑制状态（例如实体器官移植期）出现，甚至在免疫功能正常的患者中出现（尽管很少）。从致病的角度来看，PEL与卡波西氏肉瘤相关的疱疹病毒（也称为人疱疹病毒8，HHV 8）和卡波西氏肉瘤的临床前体有关。这种疾病的发病率相对较低，缺乏广泛的病因，无法更好地表征疾病，其不良结果也支持需要更深入的知识。我们在这里介绍了一名HIV阴性患者的临床生物学发现，该患者在肾移植后五年被诊断为腹膜PEL，T细胞起源，但未与HHV 8相关。

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