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首页> 外文期刊>Oncology, Gastroenterology and Hepatology Reports >Adding Low Dose Chemotherapy to Preoperative Radiotherapy in Locally Advanced Rectal Cancer: Retrospective Analysis of an Institutional Experience
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Adding Low Dose Chemotherapy to Preoperative Radiotherapy in Locally Advanced Rectal Cancer: Retrospective Analysis of an Institutional Experience

机译：在局部晚期直肠癌的术前放疗中加入低剂量化学疗法：回顾性机构经验

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Objective: Analysis was done to assess the implications and effectivity of adding chemotherapy to preoperative radiotherapy in locally advanced rectal cancer. It was priority to observe any change in resectibility with combined treatment. Methods: Twenty five patients were randomized to undergo neoadjuvant chemoradiation and were compared head on with only radiation group for locally advanced rectal cancer patients in CNCI, Kolkata. Results: Of the 25 patients in the chemoradiation arm, 20 patients (80%) were potentially resectable. In the radiation only group the number was 16 (64%). [p=0.35] Curative resection with negative margins was possible in 17 patients (68%) in the combined modality arm, as opposed to 13 patients (52%) in the other arm. [p=0.39] The failure rates in the radiation group were higher. [p= 0.49] Median Overall Survival was higher in chemoradiation group (14 months vs. 11 months) as well as median Disease free survival (14 months vs. 12 months) (p = 0.99) in comparison to only radiation group. Conclusion: As a beginner’s experience, it was very encouraging to observe the positive trend of the study and effectively this study allowed us to further proceed with different dose and schedule modulation of chemotherapy and radiotherapy to build up a definitive protocol for locally advanced Rectal cancer in our institute.
机译：目的：进行了分析以评估在局部晚期直肠癌术前放疗中增加化疗的意义和有效性。优先观察联合治疗后可切除性的任何变化。方法：将25例患者随机接受新辅助化学放疗，并与加尔各答CNCI局部晚期直肠癌患者的仅放疗组进行正面比较。结果：在放化疗组的25例患者中，有20例（80％）可能被切除。在仅放射治疗组中，该数字为16（64％）。 [p = 0.35]合并模态臂的17例患者（68％）可以进行阴性切缘的根治性切除，而另一臂的13例患者（52％）则可以。 [p = 0.39]辐射组的失败率更高。 [p = 0.49]与仅放疗组相比，化学放疗组的中位总体生存率较高（14个月vs. 11个月），中位无病生存期（14个月vs. 12个月）更高（p = 0.99）。结论：作为初学者的经验，观察该研究的积极趋势非常令人鼓舞，并且该研究有效地使我们能够继续进行不同剂量和时间表的化学疗法和放疗调节，以建立针对局部晚期直肠癌的明确方案。我们的研究所。

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