Two and Half Years Later: Cytomegalovirus and Ebstein Barr Virus Infection Leading to Sinusoidal Obstruction Syndrome in Liver Transplant Recipient

Cyriac Abby Philips; Philip Augustine; Pushpa Mahadevan

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Two and Half Years Later: Cytomegalovirus and Ebstein Barr Virus Infection Leading to Sinusoidal Obstruction Syndrome in Liver Transplant Recipient

机译：两年半后：巨细胞病毒和爱泼斯坦巴尔病毒感染导致肝移植受者正弦梗阻综合征

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Veno-occlusive disease or sinusoidal obstruction syndrome (SOS) occurring after LT is quite rare often taking a life-threatening course. The causes of SOS in a liver transplant recipient have been found to be associated with certain factors such as azathioprine use, acute rejection and tacrolimus, mostly presenting in the immediate post op period or within 3 months. However SOS occurring in a liver transplant recipient beyond 2 years has not been documented. We report a stable post-transplant recipient with dual viral (CMV and EBV) insults 2 and half years later leading to steroid and anti thymocyte globulin resistant late acute severe rejection with rapidly progressive SOS.

机译：LT后发生的静脉闭塞性疾病或窦性窦梗阻综合征（SOS）非常罕见，通常会危及生命。已发现在肝移植受者中发生SOS的原因与某些因素有关，例如硫唑嘌呤的使用，急性排斥反应和他克莫司，主要出现在手术后立即或3个月内。然而，尚无2年以上肝移植受者发生SOS的记录。我们报告了一个稳定的移植后接受者，两年半后出现双重病毒感染（CMV和EBV），导致类固醇和抗胸腺细胞球蛋白耐药，晚期急性严重排斥反应伴有快速进行性SOS。

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《Oncology, Gastroenterology and Hepatology Reports》 |2018年第1期|共3页
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Cyriac Abby Philips; Philip Augustine; Pushpa Mahadevan;
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1. Pre-transplant cytomegalovirus immunoglobulin G antibody levels could prevent severe cytomegalovirus infections post-transplant in liver transplant recipients: Experience from a tertiary care liver centre [J] . Ekta Gupta, Viniyendra Pamecha, Yogita Verma, Indian Journal of Medical Microbiology . 2017,第4期

机译：肝移植受者的移植前巨细胞病毒免疫球蛋白G抗体水平可预防严重的巨细胞病毒感染：三级保健肝脏中心的经验
2. Urgent liver transplantation for acute liver failure due to parvovirus B19 infection complicated by primary Epstein-Barr virus and cytomegalovirus infections and aplastic anaemia. [J] . So K, Macquillan G, Garas G, Internal medicine journal . 2007,第3期

机译：因细小病毒B19感染并发原发性爱泼斯坦-巴尔病毒和巨细胞病毒感染以及再生障碍性贫血而导致的急性肝衰竭的紧急肝移植。
3. Urgent liver transplantation for acute liver failure due to parvovirus B19 infection complicated by primary Epstein-Barr virus and cytomegalovirus infections and aplastic anaemia. [J] . So K, Macquillan G, Garas G, Internal medicine journal . 2007,第3期

机译：因细小病毒B19感染并发原发性爱泼斯坦-巴尔病毒和巨细胞病毒感染以及再生障碍性贫血而导致的急性肝衰竭的紧急肝移植。
4. Fecal microbiota transplantation improves outcome in pigs following co-infection with porcine reproductive and respiratory syndrome virus and porcine circovirus type 2d [C] . Annual Meeting of the American Association of Swine Veterinarians . 2018

机译：粪便微生物会移植在猪生殖和呼吸综合征病毒和猪胃肠病毒2D型猪的共感染后改善了猪的结果
5. Associations between herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), cytomegalovirus (CMV), Epstein Barr virus (EBV), human papilloma virus (HPV), Chlamydia trachomatis, Neisseria gonorrhoeae infections and preeclampsia. [D] . Rustveld, Luis Orlando. 2005

机译：1型和2型单纯疱疹病毒（HSV-1和HSV-2），巨细胞病毒（CMV），爱泼斯坦巴尔病毒（EBV），人乳头瘤病毒（HPV），沙眼衣原体，淋病奈瑟氏球菌感染和先兆子痫之间的关联。
6. Risk Factors and Utility of a Risk-Based Algorithm for Monitoring Cytomegalovirus Epstein-Barr Virus and Adenovirus Infections in Pediatric Recipients after Allogeneic Hematopoietic Cell Transplantation [O] . Evelyn Rustia, Leah Violago, Zhezhen Jin, -1

机译：异基因造血细胞移植后监测儿科患者巨细胞病毒爱泼斯坦-巴尔病毒和腺病毒感染的基于风险的算法的危险因素和实用性
7. Human Herpesvirus 6 Reactivation Is Associated with Cytomegalovirus Infection and Syndromes in Kidney Transplant Recipients at Risk for Primary Cytomegalovirus Infection [O] . Jeffrey A. DesJardin, Laurie Gibbons, Eunhui Cho, 1998

机译：人类疱疹病毒6重新激活与肾移植受者的细胞瘤感染和综合征有关，肾脏移植受者对原发性细胞病毒感染的风险有关

Two and Half Years Later: Cytomegalovirus and Ebstein Barr Virus Infection Leading to Sinusoidal Obstruction Syndrome in Liver Transplant Recipient

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