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首页> 外文期刊>Oncology, Gastroenterology and Hepatology Reports >Squamous Cell Carcinoma Arising from Perianal Fistula in HIV Positive Patient
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Squamous Cell Carcinoma Arising from Perianal Fistula in HIV Positive Patient

机译：HIV阳性患者肛周瘘引起的鳞状细胞癌

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Anal carcinomas account for 1-2% of all digestive tract cancers. They may occur in the anal canal, perianal region (up to 5cm) and surrounding skin. Squamous cell carcinoma (SCC) is the most frequent type (80%). In the last decades, the incidence of anal SCC has increased in relation with the human immunodeficiency virus (HIV) infection, especially in men who have sex with men (MSM). Individuals with impaired immunity, such HIV positive, are at higher risk of perianal diseases, which has not been altered by the introduction of highly active antiretroviral therapy. SCC arising from a perianal fistula is rare. We report a rare case of a large squamous cell carcinoma arising from a perianal fistula, in a HIV positive patient, successfully treated with chemo-radiotherapy alone with no late toxicity. Long standing perianal fistula often causes late diagnosis of perianal carcinoma. A previous history of HIV positive may increase the index of suspicion for malignancy.
机译：肛门癌占所有消化道癌的1-2％。它们可能发生在肛管，肛周区域（最大5cm）和周围的皮肤中。鳞状细胞癌（SCC）是最常见的类型（80％）。在过去的几十年中，与人类免疫缺陷病毒（HIV）感染有关，肛门SCC的发病率有所增加，尤其是在与男性发生性关系（MSM）的男性中。免疫力低下（例如HIV阳性）的个体患肛周疾病的风险更高，而采用高效抗逆转录病毒疗法并未改变这一风险。肛周瘘引起的SCC很少。我们报告了在艾滋病毒呈阳性的患者中，由肛周瘘管引起的大型鳞状细胞癌的罕见病例，仅通过化学放疗成功治疗，没有后期毒性。长期存在的肛周瘘通常会导致晚期肛周癌的诊断。先前的HIV阳性史可能会增加对恶性肿瘤的怀疑指数。

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