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首页> 外文期刊>Open Chemistry Journal >Principle, Instrumentation, and Applications of UPLC: A Novel Technique of Liquid Chromatography
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Principle, Instrumentation, and Applications of UPLC: A Novel Technique of Liquid Chromatography

机译：UPLC的原理，仪器和应用：液相色谱新技术

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摘要

The key focus of the pharmaceutical or chemical industries is to reduce the cost involved in the development of new drugs and to improve the selectivity, sensitivity, and resolution for their detection. The purpose can now be solved by the separation method called UPLC which is the modified HPLC method comprising high pressure and small sized particles (less than 2 μm) used in the column, so the length of the column decreases leading to time saving and reduction in the consumption of solvent. The underlying principle of UPLC is based on van Deemter statement which describes the connection between linear velocity with plate height. UPLC contributes to the improvement of the three areas: speed, resolution, and sensitivity. This is a new advanced category of the HPLC which has the same basic principle and methodology with improved chromatographic performance. This review is an effort to compile the principle, instrumentation, and applications of UPLC.
机译：制药或化学工业的重点是降低开发新药的成本，并提高检测新药的选择性，灵敏度和分辨率。现在，可以通过称为UPLC的分离方法解决此问题，该方法是改进的HPLC方法，该方法包括在色谱柱中使用高压和小尺寸颗粒（小于2μm），因此色谱柱的长度缩短，从而节省了时间并减少了色谱柱的使用。溶剂的消耗。 UPLC的基本原理基于van Deemter陈述，该陈述描述了线速度与板高之间的联系。 UPLC在以下三个方面做出了贡献：速度，分辨率和灵敏度。这是HPLC的一个新的高级类别，具有相同的基本原理和方法，并具有改进的色谱性能。这篇综述是对UPLC的原理，仪器和应用程序进行编译的努力。

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