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首页> 外文期刊>Open Journal of Internal Medicine >The Association between miR-196a2 rs11614913 Polymorphism and Digestive System Cancer Risk: A Meta-Analysis of 34 Studies
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The Association between miR-196a2 rs11614913 Polymorphism and Digestive System Cancer Risk: A Meta-Analysis of 34 Studies

机译：miR-196a2 rs11614913多态性与消化系统癌症风险之间的关联：对34项研究的荟萃分析

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Background: MicroRNAs (miRNAs) negatively regulate the gene expression and act as tumor suppressors or oncogenes in carcinogenesis. The association between single nucleotide polymorphism (SNP) in miR-196a2 rs11614913 and the susceptibility of digestive system cancers was inconsistent in previous studies. Methods: A standardized search of PubMed, Embase, and Cochrane library databases for publications on miR-196a2 rs11614913 polymorphism and digestive system cancer risk was performed. Then the genotype data were analyzed in a meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association. Test of heterogeneity, sensitivity analysis and assessment of publication bias were conducted in the present meta-analysis by STATA software 12.0. Results: An updated meta-analysis based on 34 independent case-control studies consisting of 13,013 cases and 16,046 controls was performed to address this association. There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations. Moreover, subgroup analysis revealed that variant C allele increased risk of colorectal carcinoma, gastric cancer and hepatocellular carcinoma (HCC), compared with wild T allele. Conclusions: There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations.
机译：背景：MicroRNA（miRNA）负调控基因表达，并在癌变过程中充当肿瘤抑制因子或致癌基因。在以前的研究中，miR-196a2 rs11614913中的单核苷酸多态性（SNP）与消化系统癌症的易感性之间存在关联。方法：对PubMed，Embase和Cochrane库数据库进行标准化搜索，以查找有关miR-196a2 rs11614913多态性和消化系统癌症风险的出版物。然后在荟萃分析中分析基因型数据。计算具有95％置信区间（CI）的几率（OR）以评估关联。在目前的荟萃分析中，通过STATA软件12.0进行了异质性测试，敏感性分析和发布偏倚评估。结果：进行了基于34个独立病例对照研究的最新荟萃分析，包括13013个病例和16046个对照，以解决这种关联。 miR-196a2 rs11614913多态性与总体消化系统癌症风险之间存在显着关联，尤其是在亚洲人群中。此外，亚组分析显示，与野生T等位基因相比，变异C等位基因增加了结直肠癌，胃癌和肝细胞癌（HCC）的风险。结论：miR-196a2 rs11614913多态性与总体消化系统癌症风险之间存在显着关联，尤其是在亚洲人群中。

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