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首页> 外文期刊>Open Journal of Internal Medicine >Prolonged QTc Interval Is an Electrophysiological Hallmark of Cirrhotic Cardiomyopathy
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Prolonged QTc Interval Is an Electrophysiological Hallmark of Cirrhotic Cardiomyopathy

机译：延长QTc间隔是肝硬化性心肌病的电生理标志

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BACKGROUND: Cirrhotic Cardiomyopathy is a relatively ill-characterized condition, which is often under-diagnosed due to absence of defined diagnostic criteria. ECG showing corrected QT Interval prolongation is the most suitable available option for diagnosis of this condition. OBJECTIVE: To determine the frequency of corrected QT interval prolongation in patients with liver cirrhosis. METHODOLOGY: Patients (n = 166) with confirmed cirrhosis, 30 years or older, presented in the outpatient and emergency department of medicine at Capital Hospital Islamabad between 1 October 2011 and 30 September 2012, were enrolled in this cross-sectional study after taking consent. ECG was done using calibrated ECG machine, and the QT Interval was measured. Corrected QT was calculated using Bazett’s formula and a QTc of more than 0.44 seconds was considered as being prolonged. RESULTS: The mean age of the patients was 57.05 ± 12.03 years. The corrected QT Interval varied from 337 ms to 560 ms. The mean QTc Interval was 429.92 ms ± 45.11. QTc was prolonged in 41 out of 166 patients (24.7%). Frequency of QTc prolongation was 4.5% in Child Pugh Grade A, 23.2% in Child Pugh Grade B, and 32.0% in Child Pugh Grade C. Association of Child Pugh Scoring with QTc prolongation was determined and found to be statistically significant (P
机译：背景：肝硬化性心肌病是一种相对较不典型的疾病，由于缺乏明确的诊断标准而常常被诊断不足。显示校正后的QT间隔延长的ECG是诊断这种情况的最合适的可用选项。目的：确定肝硬化患者校正QT间期延长的频率。方法：2011年10月1日至2012年9月30日在首都伊斯兰堡首都医院门诊和急诊科就诊的30岁或以上的确诊为肝硬化的患者（n = 166），在征得患者同意后参加了这项横断面研究。使用校准的ECG机器进行ECG，并测量QT间隔。校正后的QT是使用Bazett公式计算得出的，并且QTc超过0.44秒被认为是延长的。结果：患者的平均年龄为57.05±12.03岁。校正后的QT间隔从337毫秒变为560毫秒。平均QTc间隔为429.92 ms±45.11。 166名患者中有41名患者的QTc延长（24.7％）。 QTc延长的频率在A级儿童Pugh中为4.5％，在B级儿童中为23.2％，在C级儿童中为32.0％。确定了与PuTgh延长相关的儿童Pugh得分，并具有统计学意义（ P

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