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首页> 外文期刊>Open Journal of Obstetrics and Gynecology >Hematological Profile and Risk Factors of Anemia in Pregnant Women: A Cross Sectional Descriptive and Analytical Study in Douala Cameroon
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Hematological Profile and Risk Factors of Anemia in Pregnant Women: A Cross Sectional Descriptive and Analytical Study in Douala Cameroon

机译：孕妇贫血的血液学特征和危险因素：喀麦隆杜阿拉的横断面描述和分析研究

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During pregnancy, the hematological system undergoes numerous changes so as to meet up with the demands of the developing fetus and placenta, with major alterations in blood volume and this differs with women from different regions. The aim of this study was therefore to assess the hematological parameters and risk factors for anemia among pregnant women according to different trimesters of pregnancy in Douala, Cameroon. Methods: A cross-sectional study was conducted from February to May 2017, and all pregnant women who attended antenatal visits during our study period and who suited our inclusion criteria were recruited. The study was carried out in the antenatal care Unit of the Douala Laquintinie Hospital (DLH). A pretested questionnaire was used for the necessary data collection. Venous blood was collected from each of these women to perform a Complete Blood Count (CBC) test using an automated hematological analyzer (URIT 3010). Data were analyzed using XLSTAT 2007 and Stata version 11 software. Results: The mean age of the participants was 28 (SD = 5 years). The prevalence of anemia among pregnant women was 22% with a majority (18.4%) of these women being mildly anemic. Mean Hemoglobin values were significantly higher among women in first trimester compared to the third (12.1 ± 0.9 g/dl vs 11.8 ± 1.3 g/dl; p = 0.043). There was also a significant change in mean hematocrit (HCT) values between the first and second trimester (32.8% ± 2.5% vs 31.4% ± 2.9%, p = 0.004) and between the first and third trimester (32.8% ± 2.5% vs 30.8% ± 3.5%, p < 10~(-)4). RBC count value was higher in the first trimester than in the second trimester (3.7 ± 0.3 × 1012/L vs 3.5 ± 0.4 × 1012/L, p < 10~(-)4) and in the third trimester (3.7 ± 0.3 × 1012/L vs 3.5 ± 0.4 × 1012/L, p = 0.001). After a multivariate analysis, the following categories of women had more odds of developing anemia; women between the age range of 30 - 35 (OR = 2.81, 95%CI: 1.16 - 6.81, p = 0.023), women in the second trimester of pregnancy (OR = 2.20, 95%CI: 0.88 - 5.48, p = 0.024), women with blood group O (OR = 3.57, 95%CI: 1.41 - 16.66, p = 0.012). Conclusion: This study confirms significant variations in hematological parameters. The findings reinforce the need for supplementation and provide additional information on hematological reference values in pregnancy in Cameroon. It also helps us understand that, third trimester, age range 30 - 35, and blood group may be potential risk factors associated with anemia in pregnancy though a cohort study would be necessary to ascertain this hypothesis.
机译：在怀孕期间，血液系统发生了许多变化，以满足发育中的胎儿和胎盘的需求，血液量发生了重大变化，不同地区的女性对此有所不同。因此，本研究的目的是根据喀麦隆杜阿拉不同孕晚期孕妇的血液学参数和贫血危险因素进行评估。方法：2017年2月至2017年5月进行横断面研究，招募了在我们研究期间参加产前检查并符合我们纳入标准的所有孕妇。这项研究是在杜阿拉·拉昆蒂尼医院（DLH）的产前护理部门进行的。预先测试的问卷用于必要的数据收集。使用自动血液分析仪（URIT 3010）从这些女性中采集静脉血以进行全血细胞计数（CBC）测试。使用XLSTAT 2007和Stata 11版软件分析数据。结果：参与者的平均年龄为28岁（标准差= 5岁）。孕妇贫血的患病率为22％，其中大多数（18.4％）为轻度贫血。妊娠中期妇女的平均血红蛋白值明显高于妊娠晚期（12.1±0.9 g / dl对11.8±1.3 g / dl; p = 0.043）。孕早期和孕中期之间的平均血细胞比容（HCT）值也有显着变化（32.8％±2.5％vs 31.4％±2.9％，p = 0.004）和孕早期和孕中期之间（32.8％±2.5％vs 30.8％±3.5％，p <10〜（-）4）。早孕期的RBC计数值高于孕中期（3.7±0.3×1012 / L vs 3.5±0.4×1012 / L，p <10〜（-）4）和孕中期的RBC计数值（3.7±0.3× 1012 / L与3.5±0.4×1012 / L，p = 0.001）。经过多变量分析，以下类别的女性患贫血的几率更高; 30-35岁之间的女性（OR = 2.81，95％CI：1.16-6.81，p = 0.023），妊娠中期的女性（OR = 2.20，95％CI：0.88-5.48，p = 0.024） ），血型为O的女性（OR = 3.57，95％CI：1.41-16.66，p = 0.012）。结论：这项研究证实了血液学参数的显着变化。这些发现增加了补充营养的必要性，并提供了喀麦隆怀孕期间血液学参考值的其他信息。这也有助于我们理解，尽管有必要进行队列研究以确定该假说，但妊娠中期，年龄范围30-35岁和血型可能是与妊娠贫血相关的潜在危险因素。

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