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首页> 外文期刊>Open Journal of Obstetrics and Gynecology >The Effect of Oral Nifedipine versus Parenteral Magnesium Sulfate and Ritodrine for Tocolysis in Patients with Threatened Preterm Labor: A Randomized Controlled Trial
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The Effect of Oral Nifedipine versus Parenteral Magnesium Sulfate and Ritodrine for Tocolysis in Patients with Threatened Preterm Labor: A Randomized Controlled Trial

机译：口服硝苯地平与肠胃外硫酸镁和利托克林对早产先兆患者的子宫溶解的影响：一项随机对照试验

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Background: Preterm labor is a serious cause of neonatal morbidity and mortality. This study aims to compare the effects of nifedipine, Magnesium sul f ate and ritodrine as tocolytic drug s in patients presented with threatened preterm labor. Patients and Methods: The current study was randomized controlled trial conducted in Sohag Teaching Hospital between November 2015 and September 2016. Patients were divided into: Group A: 101 patients received intravenous ritodrine infusion ; Group B: 101 patients received intravenous magnesium sulfate ; Group C: 101 patients received oral nifedipine. Different maternal and neonatal outcomes were assessed. Results: The baseline criteria were homogenous among the study groups with no statistica lly significant differences. There is no difference between each other group regarding the need for additional tocolysis or the rate of recurrence of labour pains. Nifedipine was associated with the least length of hospital stay. There is no difference between all groups regarding the rate of preterm delivery before full steroid dose (p > 0.05). However, nifedipine group was the least one in the rate of occurrence of preterm delivery within 7 days from initiation of tocolytic therapy. Similarly, nifedipine group was associated with higher gestational age at delivery and significant prolongation of pregnancy than the other groups. Conclusion: Oral nifedipine use was associated with less recurrence of labor pains, less need for additional tocolysis, less duration of hospital stay, and more patient satisfaction in patients with threatened preterm labour.
机译：背景：早产是新生儿发病和死亡的严重原因。本研究旨在比较硝苯地平，硫酸镁和利多君作为早产先兆患者的宫缩抑制剂的作用。 患者和方法：本研究为2015年11月至2016年9月在Sohag教学医院进行的随机对照试验。患者分为：A组：101例患者接受了静脉注射利多君; B组：101例患者接受了静脉内硫酸镁治疗; C组：101例患者接受口服硝苯地平治疗。评估了不同的母亲和新生儿结局。 结果：研究组之间的基线标准是一致的，没有统计学上的显着差异。彼此之间在需要额外的宫缩溶解或分娩疼痛的复发率方面没有区别。硝苯地平与住院时间最短有关。所有组之间在类固醇完全剂量前的早产率没有差异（p> 0.05）。但是，尼可地平组在开始溶栓治疗后7天内的早产发生率中是最少的。同样，硝苯地平组与其他组相比，分娩时的胎龄高和妊娠显着延长。 结论：口服硝苯地平与劳动早产的复发次数减少，额外的宫缩术需求减少，住院时间减少以及早产先兆威胁患者的满意度更高有关。

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