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首页> 外文期刊>Open Journal of Ophthalmology >Optical Coherence Tomography Parameters in Preperimetric Open-Angle Glaucoma
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Optical Coherence Tomography Parameters in Preperimetric Open-Angle Glaucoma

机译：术前开角型青光眼的光学相干断层扫描参数

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Purpose: To evaluate the measurements of the peripapillary retinal neurofiber layers (RNFL) and the ganglion cells complex (GCC) obtained by Optical Coherence Tomography (OCT) in eyes with preperimetric open-angle glaucoma. Methods: One hundred and forty eyes of 75 patients (21 male and 54 female), 80 eyes with preperimetric glaucoma (PPG) (45 patients) and 60 normal eyes (30 subjects) were included in this study. Automated visual field examination was done to all participants using Humphrey field analyzer, program 30-2. The GCC thickness and peripapillary RNFL thickness were measured using RTVue-100 (Optivue, Inc., Fremont, CA). The areas under ROC (receiver operating characteristic)—curves (AUCs) were defined for all examined GCC and RNFL parameters. Results: GCC of the eyes with PPG was significantly thinner than GCC of the normal eyes: (89.58 vs 97.82 microns, P < 0.001). There was no significant difference between upper and lower GCC halves in both study groups. We found a reduction of RNFL thickness in glaucomatous eyes (P < 0.001) compared with normals. AUCs for GCC parameters in eyes with PPG were larger than AUCs for RNFL parameters. Conclusion: Our study showed that the peripapillary RNFL and GCC thickness are lower in preperimetric glaucoma than in normal eyes. Despite the fact that GCC measurements (especially GLV) show better AUC than peripapillary measurements, we suggest that two scans (GCC and ONH) put together are superior in detecting early structural glaucomatous damage. Several diagnostic parameters should be considered in the clinical diagnosis of preperimetric glaucoma.
机译：目的：评估通过光学相干断层扫描（OCT）获得的围手术期前开角型青光眼的眼眶周围视网膜神经纤维层（RNFL）和神经节细胞复合物（GCC）的测量结果。方法：本研究纳入了75例患者中的140眼（男性21例，女性54例），80眼围术前青光眼（PPG）（45例）和60眼正常眼（30例）。使用汉弗莱场分析仪（程序30-2）对所有参与者进行了自动视野检查。使用RTVue-100（Optivue，Inc.，Fremont，CA）测量GCC厚度和乳头周围RNFL厚度。针对所有检查的GCC和RNFL参数，定义了ROC（接收机工作特性）-曲线（AUC）下的区域。结果：PPG眼的GCC显着小于正常眼的GCC：（89.58 vs 97.82微米，P <0.001）。在两个研究组中，GCC的上半部分和下半部分之间没有显着差异。我们发现与正常人相比，青光眼眼的RNFL厚度减少（P <0.001）。 PPG眼中GCC参数的AUC大于RNFL参数的AUC。结论：我们的研究表明，围手术前青光眼的围乳头状RNFL和GCC厚度低于正常眼睛。尽管GCC测量值（尤其是GLV）显示出比乳头周围测量更好的AUC，但我们建议将两次扫描（GCC和ONH）放在一起在检测早期结构性青光眼损伤方面是优越的。在围手术期青光眼的临床诊断中应考虑几个诊断参数。

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